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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hepatitis B status in hemodialysis patients

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Author(s):
Maia Nogueira Crown GUIMARÃES [1] ; Tila FACINCANI [2] ; Sigrid De Sousa dos SANTOS [3]
Total Authors: 3
Affiliation:
[1] Universidade Federal de São Carlos. Departamento de Medicina - Brasil
[2] Universidade Federal de São Carlos. Departamento de Medicina - Brasil
[3] Universidade Federal de São Carlos. Departamento de Medicina - Brasil
Total Affiliations: 3
Document type: Journal article
Source: Arq. Gastroenterol.; v. 54, n. 4, p. 356-358, 2017-07-13.
Abstract

ABSTRACT BACKGROUND: Patients on chronic dialysis present a high prevalence of hepatitis B virus infection. Despite infection-control practices, surveillance of serological markers, and hepatitis B vaccination, there are still outbreaks of the disease in dialysis centers. OBJECTIVE: This study aims to assess the serologic and vaccination status for hepatitis B in hemodialysis patients. METHODS: This cross-sectional study assessed serologic markers and hepatitis B vaccination status of chronic kidney disease patients on regular dialysis program in São Carlos, SP, Brazil. Patients without information about hepatitis B status (anti-HBc, HBsAg and anti-HBs) were referred for testing. Individuals with uncertain or incomplete immunization status and without serological conversion (anti-HBs <10mIU/mL) were referred to vaccination, with adverse effects monitored. RESULTS: The study included 130 from a total of 181 dialysis patients. The majority were male (63.8%), mean age 53.9 years. All patients were already screened and negative for HBsAg, and 73.8% were vaccinated against hepatitis B (59.2% complete and 14.6% incomplete schedule), with a seroconversion rate of 75.3%. Only 11 (8.5%) patients had prior dosage of anti-HBc (negative). Among the 47 patients referred for anti-HBc testing, four were anti-HBc positive and one indeterminate. Of the total of patients referred to immunization, 34 have actually received HBV vaccine; among them five had mild adverse effects. CONCLUSION: Despite the benefit of dosing of anti-HBc and anti-HBs before admission to dialysis, economic constraints have reduced the screening to only HBsAg. Since occult HBV infection has already been demonstrated in hemodialysis patients, the measure of anti-HBc should be encouraged. (AU)

FAPESP's process: 13/16207-3 - Vaccinal profile of dialysis-dependent chronic renal failure population in São Carlos - SP, focus on Hepatitis B vaccine
Grantee:Maia Nogueira Crown Guimarães
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/16215-6 - Vaccinal profile of dialysis-dependent chronic renal failure population in Sao Carlos - SP, focus on yellow Fever vaccine
Grantee:Tila Facincani
Support Opportunities: Scholarships in Brazil - Scientific Initiation