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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Relevance of gutmicrobiota in cognition, behaviour and Alzheimer's disease

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De-Paula, Vanessa de J. R. [1] ; Forlenza, Andrea S. [2] ; Forlenza, Orestes V. [3]
Total Authors: 3
[1] Univ Sao Paulo, Fac Med, Hosp Clin, Inst Psiquiatria, Lab Psicobiol LIM 23, Sao Paulo, SP - Brazil
[2] Nutravie Consultoria & Educ Nutr, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Fac Med, Hosp Clin, Dept & Inst Psiquiatria, Lab Neurociencias LIM 27, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PHARMACOLOGICAL RESEARCH; v. 136, p. 29-34, OCT 2018.
Web of Science Citations: 10

Approximately 95% of the symbiotic microbes in human body are located in the gut. This microbioma is involved in important homeostatic processes, not only related to gastrointestinal function but also to several complex modulatory processes, such as glucose and bone metabolism, inflammation and immune response, peripheral (enteric) and central neurotransmission. For that reason, recent studies proposed that abnormalities in gut microbiota may play a role in systemic and central nervous system (CNS) conditions. Therefore, the integrity of gut microbiota be relevant to the pathophysiology and control of important medical diseases like diabetes mellitus, inflammatory and autoimmune diseases, and even neuropsychiatric disorders such as depression, autism spectrum disorder, Parkinson's and Alzheimer disease. Gut microbiota may affect brain function and behaviour through the microbiota-gut-brain axis, in bidirectional interplay with top-down and bottom-up regulations. Through metabolic activity of non- pathogenical microorganisms and secretion of functional by-products that increase the permeability of the intestinal mucosa, the gut microbiota influences both the production and absorption of neurotransmitters (e.g., serotonin and GABA), increasing their bioavailability to the CNS. It has been further shown some components of the gut microbiota predominantly bacteria synthesize and release amyloid peptides and lipopolysaccharides, which in turn activate inflammatory signalling through the release of cytokines, with potential effects on the pathophysiological cascade of Alzheimer disease. (AU)

FAPESP's process: 16/01302-9 - Direct and indirect pathways of glycogen synthase kinase 3B inhibition by lithium in culture of neurons
Grantee:Vanessa de Jesus Rodrigues de Paula
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/20695-3 - Effect of cholinesterase inhibitor on APP metabolism in platelets
Grantee:Tamires Alves Sarno
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 09/52825-8 - Neurobiology of Alzheimer's disease: risk markers, prognosis and therapeutic response
Grantee:Wagner Farid Gattaz
Support Opportunities: Research Projects - Thematic Grants