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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

High-fat diet increases respiratory frequency and abdominal expiratory motor activity during hypercapnia

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Author(s):
Speretta, Guilherme F. [1] ; Lemes, Eduardo Vieira [1] ; Vendramini, Regina C. [2] ; Menani, Jose V. [1] ; Zoccal, Daniel B. [1] ; Colombari, Eduardo [1] ; Colombari, Debora S. A. [1] ; Bassi, Mirian [1, 3]
Total Authors: 8
Affiliation:
[1] Sao Paulo State Univ, UNESP, Sch Dent, Dept Physiol & Pathol, Rua Humaita 1680, BR-14801903 Araraquara, SP - Brazil
[2] UNESP, Sch Pharmaceut Sci, Dept Clin Anal, Araraquara, SP - Brazil
[3] Fed Univ Santa Catarina UFSC, Biol Sci Ctr, Dept Physiol Sci, Rua Roberto Sampaio Gonzaga S-N, BR-88040900 Florianopolis, SC - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Respiratory Physiology & Neurobiology; v. 258, p. 32-39, DEC 2018.
Web of Science Citations: 1
Abstract

Breathing disorders are commonly observed in association with obesity. Here we tested whether high-fat diet (HFD) impairs the chemoreflex ventilatory response. Male Holtzman rats (300-320g) were fed with standard chow diet (SD) or HFD for 12 weeks. Then, tidal volume (V-T), respiratory frequency (f(R)) and pulmonary ventilation (V-E) were determined in conscious rats during basal condition, hypercapnia (7% or 10% CO2) or hypoxia (7% O-2). The mean arterial pressure (MAP), heart rate (HR) and baroreflex sensitivity were also evaluated in conscious rats. A group of anesthetized rats was used for the measurements of the activity of inspiratory (diaphragm) and expiratory (abdominal) muscles under the same gas conditions. Baseline f(R), V-T and V-E were similar between SD and HFD rats. During hypercapnia, the increase of f(R) was exacerbated in conscious HFD rats (60 +/- 3, vs. SD: 47 +/- 3 Delta breaths.min(-1), P < 0.05). In anesthetized rats, hypercapnia strongly increased abdominal muscle activity in HFD group (238 +/- 27, vs. basal condition: 100 +/- 0.3%; P < 0.05), without significant change in SD group (129 +/- 2.1, vs. basal condition: 100 +/- 0.8%; P = 0.34). The ventilatory responses to hypoxia were similar between groups. In conscious HFD rats, MAP and HR were elevated and the baroreflex function was impaired (P < 0.05). These data demonstrated that 12 weeks of HFD exaggerate the ventilatory response activated by hypercapnia. The mechanisms involved in these responses need more in-vestigation in future studies. (AU)

FAPESP's process: 13/17251-6 - Neural mechanisms generating the respiratory pattern and the respiratory-sympathetic coupling in conditions of hypoxia
Grantee:Daniel Breseghello Zoccal
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 13/13118-0 - Role of the melanocortin system and the renin-angiotensin system on cardiorespiratory changes in rats fed with high fat diet
Grantee:Guilherme Fleury Fina Speretta
Support type: Scholarships in Brazil - Doctorate