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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Essential oils from Tithonia diversifolia display potent anti-oedematogenic effects and inhibit acid production by cariogenic bacteria

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Sousa, Ingrid Pontes [1] ; Chagas-Paula, Daniela Aparecida [1] ; Jorge Tiossi, Renata Fabiane [1] ; Silva, Eliane de Oliveira [1] ; Miranda, Mariza Abreu [1] ; de Oliveira, Rejane Barbosa [1] ; Cropanese Spadaro, Augusto Cesar [1] ; Bastos, Jairo Kenupp [1] ; Jacometti Cardoso Furtado, Niege Aracari [1] ; Da Costa, Fernando Batista [1]
Total Authors: 10
[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Ribeirao Preto - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of Essential Oil Research; v. 31, n. 1, p. 43-52, JAN 2 2019.
Web of Science Citations: 1

Tithonia diversifolia is an invasive shrub found in the tropical regions. The aim of this study was to investigate the chemical composition as well as anti-inflammatory and antibacterial activities of the essential oils from leaves (EOL) and inflorescences (EOI) of T. diversifolia. The essential oils (EOs) were analysed by gas chromatography with flame ionization detector and coupled with mass spectrometry. EOL and EOI are mainly composed of alpha-pinene and beta-pinene. Both EOL and EOI displayed potent anti-oedematogenic properties at concentrations starting at 0.5 and 2.5% (v/v), respectively. Similar to non-steroidal anti-inflammatory drugs, both EOs inhibited oedema but did not inhibit cellular recruitment. EOI displayed more potent antimicrobial activity against cariogenic microorganisms than EOL. Both EOs significantly inhibited the production of acids by Streptococcus mutans at concentrations that were nontoxic to human gingival fibroblasts (concentrations from 25 to 125 mu g/mL for EOL and from 25 to 250 mu g/mL for EOI). (AU)

FAPESP's process: 08/02185-0 - Anti-inflammatory activity and phitochemical characterization of tea and differents extracts of Tithonia diversifolia (Asteraceae)
Grantee:Daniela Aparecida Chagas de Paula
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/01429-8 - Evaluation of essential oils activity against oral microorganisms and effect of mouthwash containing essential oil upon cariogenic microorganism biofilm
Grantee:Ingrid Pontes de Sousa
Support type: Scholarships in Brazil - Master