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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Integration of genome wide association studies and whole genome sequencing provides novel insights into fat deposition in chicken

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Moreira, Gabriel Costa Monteiro [1] ; Boschiero, Clarissa [1] ; Mello Cesar, Aline Silva [1] ; Reecy, James M. [2] ; Godoy, Thais Fernanda [1] ; Pertille, Fabio [1] ; Ledur, Monica Correa [3] ; Meira Tavares Moura, Ana Silvia Alves [4] ; Garrick, Dorian J. [5] ; Coutinho, Luiz Lehmann [1]
Total Authors: 10
[1] Univ Sao Paulo, Dept Anim Sci, Piracicaba, SP - Brazil
[2] Iowa State Univ, Dept Anim Sci, Ames, IA - USA
[3] Embrapa Suinos & Aves, Concordia, SC - Brazil
[4] Sao Paulo State Univ UNESP, FMVZ, Botucatu, SP - Brazil
[5] Massey Univ, Sch Agr, Hamilton - New Zealand
Total Affiliations: 5
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 8, NOV 1 2018.
Web of Science Citations: 4

Excessive fat deposition is a negative factor for poultry production because it reduces feed efficiency, increases the cost of meat production and is a health concern for consumers. We genotyped 497 birds from a Brazilian F-2 Chicken Resource Population, using a high-density SNP array (600 K), to estimate the genomic heritability of fat deposition related traits and to identify genomic regions and positional candidate genes (PCGs) associated with these traits. Selection signature regions, haplotype blocks and SNP data from a previous whole genome sequencing study in the founders of this chicken F2 population were used to refine the list of PCGs and to identify potential causative SNPs. We obtained high genomic heritabilities (0.43-0.56) and identified 22 unique QTLs for abdominal fat and carcass fat content traits. These QTLs harbored 26 PCGs involved in biological processes such as fat cell differentiation, insulin and triglyceride levels, and lipid biosynthetic process. Three of these 26 PCGs were located within haplotype blocks there were associated with fat traits, five overlapped with selection signature regions, and 12 contained predicted deleterious variants. The identified QTLs, PCGs and potentially causative SNPs provide new insights into the genetic control of fat deposition and can lead to improved accuracy of selection to reduce excessive fat deposition in chickens. (AU)

FAPESP's process: 15/00616-7 - Identification and characterization of CNVs in chicken genome and association with development of breast muscle
Grantee:Thaís Fernanda Godoy
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 14/08704-0 - Identification of loci of interest for poultry production
Grantee:Luiz Lehmann Coutinho
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 14/21380-9 - Genome wide association studies for fat deposition and carcass yield in chickens
Grantee:Gabriel Costa Monteiro Moreira
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 16/20440-3 - Epigenetic analysis of methylation profile of chickens submitted to different stress conditions in the livestock production environment
Grantee:Fábio Pértille
Support Opportunities: Scholarships in Brazil - Post-Doctoral
Grantee:Gabriel Costa Monteiro Moreira
Support Opportunities: Scholarships abroad - Research Internship - Doctorate