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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Conjugation of antifungal benzoic acid derivatives as a path for detoxification in Penicillium brasilianum, an endophyte from Melia azedarach

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Fill, Taicia Pacheco [1] ; Pallini, Heloisa Fassina [2] ; Din, Zia Ud [2] ; Jurberg, Igor Dias [1] ; da Silva, Jose Vinicius [2] ; Rodrigues-Filho, Edson [2]
Total Authors: 6
[1] Univ Estadual Campinas, Inst Chem, CP 6154, BR-13083970 Campinas, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Chem, CP 676, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: BIOORGANIC CHEMISTRY; v. 81, p. 367-372, DEC 2018.
Web of Science Citations: 0

In this study, the consumption of 4-bromobenzoic acid and 4-chlorobenzoic acid by the fungus Penicillium brasilianum, an endophyte from Melia azedarach is evaluated. This fungus metabolizes these halobenzoic acids to produce three new brominated compounds, which have been isolated and characterized, and three new chlorinated derivatives identified by HRMS. Among these products, (4-bromobenzoyl)proline has been also chemically synthesized and employed in biological assays, thus providing insights for the elucidation of the defense mechanism of P. brasilianum towards these halobenzoic acids. (AU)

FAPESP's process: 10/11384-6 - Biotransformation of natural and synthetic products using endophytic microorganisms, a chemical-ecologycal approach for the production of bioactive substances
Grantee:Edson Rodrigues Filho
Support Opportunities: Regular Research Grants
FAPESP's process: 15/10384-6 - Biosynthetic studies involving bottom-up approaches of polyketides produced by Penicillium species
Grantee:Taicia Pacheco Fill
Support Opportunities: Regular Research Grants