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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Beet Stalks and Leaves (Beta vulgaris L.) Protect Against High-Fat Diet-Induced Oxidative Damage in the Liver in Mice

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Lorizola, Isabela M. [1] ; Furlan, Cibele P. B. [2] ; Portovedo, Mariana [1] ; Milanski, Marciane [1] ; Botelho, Patricia B. [3] ; Bezerra, Rosangela M. N. [1] ; Sumere, Beatriz R. [1] ; Rostagno, Mauricio A. [1] ; Capitani, Caroline D. [1]
Total Authors: 9
[1] Univ Estadual Campinas, Sch Appl Sci, BR-13484350 Limeira, SP - Brazil
[2] Univ Estadual Campinas, Dept Food & Nutr DEPAN, Fac Food Engn FEA, BR-13484350 Campinas, SP - Brazil
[3] Univ Fed Goias, Fac Nutr FANUT, BR-74605080 Goiania, Go - Brazil
Total Affiliations: 3
Document type: Journal article
Source: NUTRIENTS; v. 10, n. 7 JUL 2018.
Web of Science Citations: 6

Some flavonoids identified in beet stalks can help the antioxidant endogenous defenses during a chronic inflammation process. The current study investigates the effect of polyphenols present in beet stalks and leaves on liver oxidative damage in mice fed a high-fat diet (HF). The control (CT) or HF diet groups were supplemented with dehydrated beet stalks and leaves (SL) or beet stalk and leaf ethanolic extract (EX). In terms of Vitexin-rhaminoside equivalents (VRE), EX groups received similar to 5.91 mg of VRE100 g(-1) diet, while the SL groups received similar to 3.07 mg VRE100 g(-1) diet. After 8 weeks, we evaluated fasting blood glucose; cholesterol, hepatic Malondialdehyde (MDA) levels and hepatic Glutathione (GSH), Glutathione peroxidase (GPx), Glutathione reductase (GR) and Superoxide dismutase (SOD) activity. Dehydrated beet stalks and leaves (HFSL) attenuated the deleterious effects of a HF diet on lipid metabolism, reduced fasting blood glucose levels, ameliorated cholesterol levels and reduced GPx and GR activities (p < 0.05) compared to the HF group. However; the addition of ethanolic extract from beet stalks and leaves was unable (p > 0.05) to prevent the liver damage caused by HF diet in mice. The presence of flavonoids, such as Vitexin derivatives in beet stalks and leaves can help the liver damage induced by HF diet. (AU)

FAPESP's process: 13/04304-4 - Development of integrated systems for the analysis of bioactive compounds in natural products employing supercritical technology
Grantee:Maurício Ariel Rostagno
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 15/15035-0 - Metabolic parameters and hepatic gluconeogenesis on hyperlipidemia mice induced by high-fat diet supplemented with beetroot stalks and leaves (beta vulgaris l.)
Grantee:Caroline Dario Capitani
Support Opportunities: Regular Research Grants
FAPESP's process: 13/18498-5 - Effect of beetroot (Beta vulgaris L .) by-products on oxidative stress of high-fat diet rats
Grantee:Isabela Micheletti Lorizola
Support Opportunities: Scholarships in Brazil - Scientific Initiation