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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Short-term exposure to dexamethasone promotes autonomic imbalance to the heart before hypertension

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Duchatsch, Francine [1, 2] ; Constantino, Paula B. [1, 2] ; Herrera, Naiara A. [1, 2] ; Fabricio, Mayara F. [1, 2] ; Tardelli, Lidieli P. [1, 2] ; Martuscelli, Aline M. [2] ; Dionisio, Thiago J. [3] ; Santos, Carlos F. [3] ; Amaral, Sandra L. [1, 2]
Total Authors: 9
[1] UNESP, Joint Grad Program Physiol Sci, PIPGCF UFSCar, Sao Carlos, SP - Brazil
[2] Sao Paulo State Univ, UNESP, Sci Fac, Dept Phys Educ, Bauru, SP - Brazil
[3] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Bauru, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION; v. 12, n. 8, p. 605-613, AUG 2018.
Web of Science Citations: 0

Hypertension is one of the chronic side effects of dexamethasone (DEX) treatment; however, almost nothing is known about its acute effects. Therefore, the aim of this study was to investigate the possible mechanisms involved in blood pressure control after acute or short-term DEX treatment in adult animals. Eighty Wistar rats were divided into four groups: C1 and C5, for rats treated with saline for 1 or 5 days, respectively; D1 and D5, for rats treated with DEX for 1 or 5 days, respectively (decadron, 1 mg/kg, i.p.). Heart rate was increased in DEX treatment, but arterial pressure and cardiac muscle mass were not altered. Only few and isolated changes on gene expression and protein level of renin-angiotensin system components were observed. Five days of DEX treatment, but not one day, determined an increase in sympathetic component of spectral analysis (+75.93%, P <.05) and a significant reduction of parasympathetic component (-18.02%, P <.05), which contributed to the autonomic imbalance to the heart (LF/HF, +863.69%). The results of this present study demonstrated, for the first time, that short-term exposure to DEX treatment impairs the autonomic balance to the heart before hypertension, which was independent of renin-angiotensin system. (C) 2018 American Heart Association. All rights reserved. (AU)

FAPESP's process: 14/23050-6 - Effects of dexamethasone short-time treatment: role of renin-angiotensin-system and autonomic nervous system
Grantee:Francine Duchatsch Ribeiro de Souza
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 15/03965-2 - Role of the renin-angiotensin system in different oral inflammatory models: an experimental interdisciplinary and clinical approach
Grantee:Carlos Ferreira dos Santos
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 12/19722-3 - Physical precinditioning effects on Dexamethasone-induced hypertensio: role of Renin-Angiotensin System
Grantee:Paula Bessi Constantino Prazeres
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 14/23229-6 - Physical training effects on hypertension, arterial stiffness and muscle atrophy induced by dexamethasone: role of oxidative stress
Grantee:Sandra Lia do Amaral Cardoso
Support Opportunities: Regular Research Grants