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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A Fatal Bacteremia Caused by Hypermucousviscous KPC-2 Producing Extensively Drug-Resistant K64-ST11 Klebsiella pneumoniae in Brazil

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Author(s):
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de Campos, Tatiana Amabile [1] ; Goncalves, Laura Fernandes [1] ; Magalhaes, Kelly Grace [1] ; Martins, Vicente de Paulo [1] ; Pappas Junior, Georgios Joannis [1] ; Peirano, Gisele [2] ; Pitout, Johann D. D. [2] ; Goncalves, Guilherme Bartolomeu [3] ; Rueda Furlan, Joao Pedro [3] ; Stehling, Eliana Guedes [3] ; Pitondo-Silva, Andre [4]
Total Authors: 11
Affiliation:
[1] Univ Brasilia, Inst Biol Sci, Dept Cell Biol, Brasilia, DF - Brazil
[2] Univ Calgary, Dept Pathol & Lab Med, Calgary, AB - Canada
[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Toxicol & Bromatol Anal, Ribeirao Preto - Brazil
[4] Univ Ribeirao Preto, Sch Dent, Ribeirao Preto - Brazil
Total Affiliations: 4
Document type: Journal article
Source: FRONTIERS IN MEDICINE; v. 5, SEP 21 2018.
Web of Science Citations: 2
Abstract

We report a fatal bacteremia caused by Klebsiella pneumoniae in a 60-70-year-old patient from Brazil. The genomic analysis of three isolates (from blood culture, nasal and anal swabs) showed that the bacteremia was caused by a KPC-2 producing extensively drug-resistant K64-ST11 hypermucousviscous K. pneumoniae (hmKP) harboring several virulence and antimicrobial resistance genes. Although the isolates did not present virulence markers associated with hypervirulent K. pneumoniae (hvKP), they showed invasion and toxicity to epithelial Hep-2 cells; resistance to cell microbicidal mechanisms; and blood and human serum survival, evidencing their pathogenic potential. This study highlights the risk of infection caused by hmKp strains not characterized as hvKP as well as the clinical implications and difficulty of treatment, especially in elderly or immunocompromised patients. (AU)

FAPESP's process: 13/22581-5 - Study of pathogenic mechanisms and correlation with antimicrobial resistance of Klebsiella pneumoniae from Brazil and other countries across five continents
Grantee:André Pitondo da Silva
Support Opportunities: Research Grants - Young Investigators Grants