| Full text | |
| Author(s): |
Total Authors: 3
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| Affiliation: | [1] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Rua Prof Artur Riedel 275, BR-09972270 Diadema, SP - Brazil
Total Affiliations: 1
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| Document type: | Journal article |
| Source: | Clinica Chimica Acta; v. 485, p. 3583-3585, OCT 2018. |
| Web of Science Citations: | 0 |
| Abstract | |
Total syntheses of (+)-bernumidine and its unnatural enantiomer were accomplished through chemoenzymatic dynamic kinetic resolution and ruthenium(II)-catalyzed enantioselective hydrogenation, which provided (R)-salsolidine propyl carbamate and N-acetyl (S)-salsolidine in high yields and enantiomeric excesses, respectively. Both enantiomers of salsolidine were accessed and converted into (+)- and (-)-bernumidine via simple and efficient transformations. (C) 2018 Elsevier Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 17/21990-0 - 2-(Trialkylsilyl)aryl trifluoromethanesulfonates as aryne precursors in the development of methodologies for obtaining nitrogen-containing heterocyclic compounds and total syntheses of bioactive natural products |
| Grantee: | Cristiano Raminelli |
| Support Opportunities: | Regular Research Grants |