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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of the prebiotic mannan oligosaccharide on the experimental periodontitis in rats

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Levi, Yara L. A. S. [1] ; Novais, Gabriela S. [1] ; Dias, Raisa B. [1] ; Andraus, Rodrigo A. C. [2] ; Messora, Michel R. [3] ; Neto, Hermann B. [4] ; Ervolino, Edilson [5] ; Santinoni, Carolina S. [1] ; Maia, Luciana P. [1, 6]
Total Authors: 9
[1] Univ Western Sao Paulo UNOESTE, Grad Program Dent GPD Masters Degree, Presidente Prudente, SP - Brazil
[2] Univ Pitagoras UNOPAR, Grad Program Rehabil Sci, Londrina, Parana - Brazil
[3] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Oral & Maxillofacial Surg & Periodontol, Ribeirao Preto, SP - Brazil
[4] Univ Western Sao Paulo UNOESTE, Dept Funct Sci, Presidente Prudente, SP - Brazil
[5] Univ Estadual Paulista UNESP, Dent Sch Aracatuba, Dept Basic Sci, Div Histol, Aracatuba, SP - Brazil
[6] Univ Pitagoras UNOPAR, Grad Program Dent, Londrina, Parana - Brazil
Total Affiliations: 6
Document type: Journal article
Source: JOURNAL OF CLINICAL PERIODONTOLOGY; v. 45, n. 9, p. 1078-1089, SEP 2018.
Web of Science Citations: 0

AimTo evaluate the effect of the prebiotic (PREB) mannan oligosaccharide (MOS) on the progression of the experimental periodontitis (EP) and intestinal morphology in rats. Materials and MethodsForty rats were randomly allocated into groups (n=10): C (control), PREB, EP and EP-PREB. Groups PREB and EP-PREB received MOS incorporated into the feed daily. After 30days, groups EP and EP-PREB received a cotton ligature around their mandibular first molars, kept for 14days. Morphometrical, histomorphometrical, microcomputed tomography, gene expression analyses and immunohistochemistry were performed. Data were statistically analysed (p<0.05). ResultsGroup EP-PREB showed less interproximal bone loss, area without bone in the furcation and bone porosity, and greater bone mineral density than group EP (p<0.05). It was also observed a significant decrease in IL-10 and IFN- gene expression, besides a decrease in TNF- and IL-1 and an increase in TGF- immunolabeling score for group EP-PREB. Group EP-PREB also presented villous height and crept depth values similar to group C, while group EP presented reduced values (p<0.05). ConclusionIt can be concluded that the oral administration of MOS promotes a protective effect against alveolar bone loss caused by EP in rats, modifying histologic and immune-inflammatory parameters, in addition to protecting the intestine. (AU)

Grantee:Luciana Prado Maia
Support Opportunities: Regular Research Grants