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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Seroconversion for Cytomegalovirus Infection During Pregnancy and Fetal Infection in a Highly Seropositive Population: ``The BraCHS Study{''}

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Author(s):
Mussi-Pinhata, Marisa M. [1] ; Yamamoto, Aparecida Y. [1] ; Aragon, Davi C. [1] ; Duarte, Geraldo [2] ; Fowler, Karen B. [3] ; Boppana, Suresh [3] ; Britt, William J. [3]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pediat, Sao Paulo - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Gynecol & Obstet, Sao Paulo - Brazil
[3] Univ Alabama Birmingham, Dept Pediat, Birmingham, AL - USA
Total Affiliations: 3
Document type: Journal article
Source: Journal of Infectious Diseases; v. 218, n. 8, p. 1200-1204, OCT 15 2018.
Web of Science Citations: 5
Abstract

We determined the risk of seroconversion in seronegative pregnant women living in a high seroprevalence population. Cytomegalovirus (CMV)-immunoglobulin G reactivity was determined at the 1st trimester in all women and sequentially for seronegative women. A total of 1915 of 1952 (98.1%; 95% confidence interval {[}CI], 97.4%-98.7%) women were seropositive, and 36 (1.8%; 95% CI, 1.3%-2.6%) were seronegative. Five of the 36-seronegative women seroconverted for a cumulative rate of 13.9% (95% CI, 4.8%-30.6%). Congenital CMV infection was diagnosed in 1 of 36 infants (2.8%; 95% CI, 0.5%-63.9%) born to seronegative women compared with 8 of 1685 (0.5%; 95% CI, 0.2%-1.0%) infants born to seropositive mothers. Even with a high risk of primary infection in seronegative women, most CMV-infected infants were born to women with pre-existing seroimmunity. (AU)

FAPESP's process: 13/06579-0 - Brazilian congenital cytomegalovirus, hearing and maternal secondary infection study (BraCHS Study)
Grantee:Marisa Marcia Mussi
Support type: Research Projects - Thematic Grants