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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Current Advances in Immunological Studies on the Vespidae Venom Antigen 5: Therapeutic and Prophylaxis to Hypersensitivity Responses

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Author(s):
Bazon, Murilo Luiz [1] ; Silveira, Lais Helena [1] ; Simioni, Patricia Ucelli [2] ; Brochetto-Braga, Marcia Regina [3, 1]
Total Authors: 4
Affiliation:
[1] Univ Estadual Paulista, LBMA IB RC UNESP, Av 24-A, 1515, BR-13506900 Rio Claro, SP - Brazil
[2] FAM, Fac Amer, Dept Biomed, Av Joaquim Boer 733, BR-13477360 Americana, SP - Brazil
[3] Univ Estadual Paulista, CEVAP, Rua Jose Barbosa de Barros 1780, BR-18610307 Botucatu, SP - Brazil
Total Affiliations: 3
Document type: Review article
Source: TOXINS; v. 10, n. 8 AUG 2018.
Web of Science Citations: 1
Abstract

Although systemic reactions caused by allergenic proteins present in venoms affect a small part of the world population, Hymenoptera stings are among the main causes of immediate hypersensitivity responses, with risk of anaphylactic shock. In the attempt to obtain therapeutic treatments and prophylaxis to hypersensitivity responses, interest in the molecular characterization of these allergens has grown in the scientific community due to the promising results obtained in immunological and clinical studies. The present review provides an update on the knowledge regarding the immune response and the therapeutic potential of Antigen 5 derived from Hymenoptera venom. The results confirm that the identification and topology of epitopes, associated with molecular regions that interact with antibodies, are crucial to the improvement of hypersensitivity diagnostic methods. (AU)

FAPESP's process: 14/13936-7 - Allergens from venom of the social wasp Polybia paulista (Hymenoptera, Vespidae): recombinant expression in yeast for improved diagnosis and specific immunotherapy to Hymenoptera venom allergy
Grantee:Márcia Regina Brochetto Braga
Support type: Regular Research Grants
FAPESP's process: 17/18422-0 - Evaluation of the effects of Polybia venom antigen 5 (Hymenoptera, Vespidae) in the recombinant form on the production of inflammatory and immunological mediators in vitro for the development of a diagnostic kit
Grantee:Márcia Regina Brochetto Braga
Support type: Regular Research Grants