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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Post-stroke BDNF Concentration Changes Following Physical Exercise: A Systematic Review

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Alcantara, Carolina C. [1] ; Garcia-Salazar, Luisa F. [1, 2] ; Silva-Couto, Marcela A. [1] ; Santos, Gabriela L. [1] ; Reisman, Darcy S. [3] ; Russo, Thiago L. [1]
Total Authors: 6
[1] Univ Fed Sao Carlos, Phys Therapy Dept, Lab Neurol Physiotherapy Res, Sao Carlos, SP - Brazil
[2] Univ Rosario, Escuela Med & Ciencias Salud, GI Ciencias Rehab, Bogota - Colombia
[3] Univ Delaware, Dept Phys Therapy, Newark, DE - USA
Total Affiliations: 3
Document type: Review article
Source: FRONTIERS IN NEUROLOGY; v. 9, AUG 28 2018.
Web of Science Citations: 6

Background: Research over the last two decades has highlighted the critical role of Brain-derived neurotrophic factor (BDNF) in brain neuroplasticity. Studies suggest that physical exercise may have a positive impact on the release of BDNF and therefore, brain plasticity. These results in animal and human studies have potential implications for the recovery from damage to the brain and for interventions that aim to facilitate neuroplasticity and, therefore, the rehabilitation process. Purpose: The aim of this study was to carry out a systematic review of the literature investigating how aerobic exercises and functional task training influence BDNF concentrations post-stroke in humans and animal models. Data Sources: Searches were conducted in PubMed (via National Library of Medicine), SCOPUS (Elsevier), CINAHL with Full Text (EBSCO), MEDLINE 1946-present with daily updates (Ovid) and Cochrane. Study Selection: All of the database searches were limited to the period from January, 2004 to May, 2017. Data Extraction: Two reviewers extracted study details and data. The methodological quality of the studies that used animal models was assessed using the ARRIVE Guidelines, and the study that evaluated human BDNF was assessed using the PEDro Scale. Data Synthesis: Twenty-one articles were included in this review. BDNF measurements were performed systemically (serum/plasma) or locally (central nervous system). Only one study evaluated human BDNF concentrations following physical exercise, while 20 studies were experimental studies using a stroke model in animals. A wide variation was observed in the training protocol between studies, although treadmill walking was the most common type of intervention among the studies. Studies were of variable quality: the studies that used animal models scored from 8/20 to 15/20 according to the ARRIVE Guidelines. The only study that evaluated human subjects scored 5/10 according to the PEDro scale and, which indicates a quality classified as ``fair{''}. Conclusions: The results of the current systematic review suggest that aerobic exercise promotes changes in central BDNF concentrations post-stroke. On the other hand, BDNF responses following functional exercises, such as reaching training and Constraint Induced Movement Therapy (CIMT), seem to be still controversial. Given the lack of studies evaluating post-stroke BDNF concentration following physical exercise in humans, these conclusions are based on animal work. (AU)

FAPESP's process: 17/13655-6 - Sedentary behaviour and arterial dysfunction in chronic post-stroke subjects
Grantee:Thiago Luiz de Russo
Support Opportunities: Regular Research Grants
FAPESP's process: 13/25805-1 - Immediate effects of cryotherapy on neuromuscular performance of ankle joint and on gait pattern of chronic spastic hemiparetic subjects post stroke
Grantee:Carolina Carmona de Alcântara
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 15/19197-4 - Effects of gradual or abrupt speed changes on post-stroke locomotor learning and transfer
Grantee:Carolina Carmona de Alcântara
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 15/21695-2 - Features and Statistical Parametric Mapping (SPM) analysis for kinematic and EMG data during upper limb functional tasks of chronic hemiparetic subjects
Grantee:Gabriela Lopes dos Santos
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 14/25845-6 - Effects of elastic tape on shoulder proprioception and sensory-motor performance during reaching in chronic hemiparetic subjects
Grantee:Gabriela Lopes dos Santos
Support Opportunities: Scholarships in Brazil - Doctorate