Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In vitro basal T-cell proliferation among asymptomatic Human T cell Leukemia Virus type 1 patients co-infected with hepatitis C and/or Human Immunodeficiency Virus type 1

Full text
Author(s):
Assone, Tatiane [1, 2] ; Kanashiro, Tatiana M. [1] ; Baldassin, Maira P. M. [1] ; Paiva, Arthur [1, 2] ; Haziot, Michel E. [3] ; Smid, Jerusa [3] ; de Oliveira, Augusto Penalva [3] ; Fonseca, Luiz Augusto M. [4] ; Norris, Philip J. [5, 6] ; Casseb, Jorge [1, 2]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Fac Med, Dept Dermatol, Lab Invest Dermatol & Imunodeficiencias, Sao Paulo, SP - Brazil
[2] Inst Med Trop Sao Paulo, Sao Paulo, SP - Brazil
[3] Inst Doencas Infecciosas Emilio Ribas IIER, Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Fac Med, Dept Med Prevent, Sao Paulo, SP - Brazil
[5] Blood Syst Res Inst, San Francisco, CA - USA
[6] Univ Calif San Francisco, San Francisco, CA 94143 - USA
Total Affiliations: 6
Document type: Journal article
Source: Brazilian Journal of Infectious Diseases; v. 22, n. 2, p. 106-112, MAR-APR 2018.
Web of Science Citations: 0
Abstract

Background: Infection with Human T cell Leukemia Virus type 1 can be associated with myelopathy/tropical spastic paraparesis (HAM/TSP) and other inflammatory diseases. Lymphocytes from about half of Human T cell Leukemia Virus type 1-infected subjects spontaneously proliferate in vitro, and how this phenomenon relates to symptomatic disease and viral burden is poorly understood. Objective: To evaluate T-cell proliferation in vitro among patients co-infected with Human T cell Leukemia Virus type 1/Hepatitis C Virus/Human Immunodeficiency Virus type 1. Material and methods: From 610 Human T cell Leukemia Virus-infected patients of the Human T cell Leukemia Virus outpatient clinic from Institute of Infectious Diseases ``Emilio Ribas{''} in Sao Paulo, 273 agreed to participate: 72 had HAM/TSP (excluded from this analysis) and 201 were asymptomatic, a classification performed during a regular neurological appointment. We selected the subgroup made up only by the 201 asymptomatic subjects to avoid bias by the clinical status as a confounder effect, who had laboratory results of Human T cell Leukemia Virus type 1 proviral load and T-cell proliferation assay in our database. They were further grouped according to their serological status in four categories: 121 Human T cell Leukemia Virus type 1 asymptomatic mono-infected carriers; 32 Human T cell Leukemia Virus type 1/Hepatitis C Virus, 29 Human T cell Leukemia Virus type 1/Human Immunodeficiency Virus type 1, and 19 Human T cell Leukemia Virus type 1/Human Immunodeficiency Virus type 1/Hepatitis C Virus co-infected patients. Clinical data were obtained from medical records and interviews. DNA Human T cell Leukemia Virus type 1 proviral load (PVL) and T-cell proliferation (LPA) assay were performed for all samples. Results: From a total of 273 subjects with Human T cell Leukemia Virus type 1, 80 presented co-infections: 29 had Human Immunodeficiency Virus type 1, 32 had Hepatitis C Virus, and 19 had Human Immunodeficiency Virus type 1 and Hepatitis C Virus. Comparing the groups based on their serological status, independently of being asymptomatic carriers, we observed a significant increase of PVL (p < 0.001) and LPA (p =0.001). However, when groups were stratified according to their clinical and serological status, there was no significant increase in Human T cell Leukemia Virus type 1 PVL and LPA. Conclusion: No significant increase of basal T-cell proliferation among Human T cell Leukemia Virus type 1 co-infected was observed. This interaction may be implicated in liver damage, worsening the prognosis of co-infected patients or, on the contrary, inducing a higher spontaneous clearance of Hepatitis C Virus infection in Human T cell Leukemia Virus type 1 co-infected patients. (C) 2018 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. (AU)

FAPESP's process: 12/23397-0 - Determination of IL28B polymorphism profile in patients co-infected with Chronic Hepatitis C (HCV) virus and human T-lymphotropic type 1 (HTLV-1)
Grantee:Jorge Simão do Rosário Casseb
Support Opportunities: Regular Research Grants
FAPESP's process: 14/22827-7 - Prevalence and incidence of early central nervous system disturbance in HTLV-1-infected subjects in Brazil
Grantee:Jorge Simão do Rosário Casseb
Support Opportunities: Regular Research Grants