Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Restricted lesions of the ventrolateral or dorsal columns of the periaqueductal gray promotes distinct effects on tonic immobility and defensive analgesia in guinea pigs

Full text
Author(s):
Vieira-Rasteli, Eveline Bis [1] ; de Paula, Bruna Balbino [1] ; de Paiva, Yara Bezerra [2] ; Coimbra, Norberto Cysne [2] ; Andrade Leite-Panissi, Christie Ramos [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Sch Philosophy Sci & Literature Ribeirao Preto, Dept Psychol, BR-14040901 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Med Sch Ribeirao Preto, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Physiology & Behavior; v. 194, p. 538-544, OCT 1 2018.
Web of Science Citations: 3
Abstract

Tonic immobility (TI) is an innate defensive response exhibited by prey when physical contact with a predator is prolonged and inescapable. This defensive response is able to activate analgesia mechanisms; this activation has adaptive value because, during an attack by a predator, the manifestation of recuperative behaviors can affect the appropriate behavioral defense strategy. Some studies have suggested that similar structures of the central nervous system can regulate the response of both TI and nociception. Thus, this study evaluated the effect of chemical lesion through the administration of ibotenic acid in restricted brain areas of the periaqueductal gray matter (PAG) in guinea pig on the TI response and nociception evaluated in the hot plate test before and after emission of TI. The data showed that an irreversible chemical lesion in the ventrolateral PAG reduced of the TI response as well as defensive antinociception. However, a lesion in the dorsal PAG blocked the defensive antinociception induced by TI but did not alter TI duration. In summary, one could hypothesize that the neural substrates responsible for defensive behavior and antinociception represent similar systems that are distinct in modulation. Thus, the ventrolateral PAG has been associated with the modulation of TI and the defensive antinociception induced by TI. In contrast, the integrity of the dorsal PAG should be necessary for defensive antinociception to occur but not to elicit TI behavior in guinea pigs. (AU)

FAPESP's process: 07/06549-3 - Evaluation of the defensive behavior of tonic immobility and of the nociceptive after restricted lesions in structures of the aversive cerebral system.
Grantee:Eveline Bis Vieira Rasteli
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 05/00096-1 - Functional anatomy evaluation of the defensive behavior of tonic immobility in guinea pigs
Grantee:Christie Ramos Andrade Leite Panissi
Support type: Regular Research Grants