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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Dietary Selenium Intake and Subclinical Hypothyroidism: A Cross-Sectional Analysis of the ELSA-Brasil Study

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Andrade, Gustavo R. G. [1] ; Gorgulho, Bartira [2] ; Lotufo, Paulo A. [3] ; Bensenor, Isabela M. [3] ; Marchioni, Dirce M. [1]
Total Authors: 5
[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-03178200 Sao Paulo - Brazil
[2] Univ Fed Mato Grosso, Sch Nutr, Dept Food & Nutr, BR-78060900 Cuiaba - Brazil
[3] Univ Sao Paulo, Univ Hosp, Clin & Epidemiol Res Ctr, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: NUTRIENTS; v. 10, n. 6 JUN 2018.
Web of Science Citations: 2

Selenium (Se) participates in several enzymatic reactions necessary for regulating the homeostasis of thyroid hormones. We aimed to analyze the association between dietary Se intake and subclinical hypothyroidism. Baseline data from the Longitudinal Study of Adult Health (Estudo Longitudinal de Saude do Adulto-ELSA-Brasil) in Brazil were analyzed, with a final sample size of 14,283 employees of both sexes aged 35-74 years. Dietary data was collected using a previously validated food frequency questionnaire. Subclinical hypothyroidism was categorized as thyroid-stimulating hormone levels of >4.0 IU/mL and free prohormone thyroxine levels within normal limits, without administering drugs for thyroid disease. A multiple logistic regression model was used to assess the relationship between the presence of subclinical hypothyroidism and tertiles of Se consumption. The prevalence of subclinical hypothyroidism in the study sample was 5.4% (95% confidence interval {[}CI], 3.8-7.0%). Compared with the first tertile of Se intake, the second (odds ratio {[}OR], 0.79; 95% CI, 0.65-0.96%) and third (OR, 0.72; 95% CI, 0.58-0.90%) tertiles were inversely associated with subclinical hypothyroidism, however further research is needed to confirm the involvement of Se in subclinical hypothyroidism using more accurate methodologies of dietary assessment and nutritional status to evaluate this relationship. (AU)

FAPESP's process: 16/22077-3 - Association between the profile of risk factors for cardiovascular disease with emphasis on factors associated with diet as selenium deficiency and TSH levels/T4-free and thyroid function
Grantee:Gustavo Rosa Gentil Andrade
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 11/12256-4 - Calcium score and coronary atherosclerosis in an adult cohort
Grantee:Paulo Andrade Lotufo
Support Opportunities: Regular Research Grants