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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

AMPA receptor trafficking and its role in heterosynaptic plasticity

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Antunes, G. [1] ; Simoes-de-Souza, F. M. [1]
Total Authors: 2
[1] Fed Univ ABC, Ctr Math Computat & Cognit, Sao Bernardo Do Campo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 8, JUL 9 2018.
Web of Science Citations: 2

Historically, long-term potentiation (LTP) and long-term depression (LTD), the best-characterized forms of long-term synaptic plasticity, are viewed as experience-dependent and input-specific processes. However, cumulative experimental and theoretical data have demonstrated that LTP and LTD can promote compensatory alterations in non-stimulated synapses. In this work, we have developed a computational model of a tridimensional spiny dendritic segment to investigate the role of AMPA receptor (AMPAR) trafficking during synaptic plasticity at specific synapses and its consequences for the populations of AMPAR at nearby synapses. Our results demonstrated that the mechanisms of AMPAR trafficking involved with LTP and LTD can promote heterosynaptic plasticity at non-stimulated synapses. These alterations are compensatory and arise from molecular competition. Moreover, the heterosynaptic changes observed in our model can modulate further activity-driven inductions of synaptic plasticity. (AU)

FAPESP's process: 14/08481-0 - Computational modeling of the postsynaptic mechanisms of the dopaminergic and glutamatergic integration in a hippocampal dendritic spine in health and pathological conditions
Grantee:Gabriela Antunes
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/18825-4 - Computing language with mirror neurons
Grantee:Fábio Marques Simões de Souza
Support Opportunities: Research Grants - Research Partnership for Technological Innovation - PITE
FAPESP's process: 15/50122-0 - Dynamic phenomena in complex networks: basics and applications
Grantee:Elbert Einstein Nehrer Macau
Support Opportunities: Research Projects - Thematic Grants