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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biologically Active Orbitides from the Euphorbiaceae Family

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Ramalhol, Suelem D. [1] ; Pinto, Meri Emili F. [1] ; Ferreira, Douglas [2] ; Bolzani, Vanderlan S. [1]
Total Authors: 4
[1] Sao Paulo State Univ UNESP, Inst Chem, Prof Francisco Degni St, BR-14800060 Araraquara, SP - Brazil
[2] Fed Univ Western Bahia UFOB, Luis Eduardo Magalhaes, BA - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Planta Medica; v. 84, n. 9-10 JUL 2018.
Web of Science Citations: 9

A comprehensive overview of natural orbitides isolated from Euphorbiaceae species and their most relevant biological activities are presented. Euphorbiaceae is a large and diverse family, which comprises about 300 genera, and is known as an important source of medicines and toxins. Several classes of secondary metabolites have been described for this taxon, however, orbitides have been broadly reported in Jatropha and Croton genera. Additionally, the latex is documented as the main source of orbitides in this family. Based on their structural and functional diversity, orbitides present a large variety of biological activities described as cytotoxicity, antimalarial, antibacterial, antifungal, enzymatic inhibition, and immunosuppressive, although the mechanism of action still needs to be further investigated. In recent years, the discovery of bioactive cyclic peptides from different sources has grown exponentially, making them promising molecules in the search for new drug leads. This review also highlights the attempts made by many researchers to organize the orbitides nomenclature and amino acid numbering, as well the important progress recently achieved in the biosynthetic study area. (AU)

FAPESP's process: 15/09533-7 - Cyclopeptides of Extreme Environments Plants (Caatinga Biome): Characterization, Function, Synthesis and Evaluation of Anti-tumor and Immunosuppressive Activities
Grantee:Suelem Demuner Ramalho
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC