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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Polyphenol-rich green tea extract improves adipose tissue metabolism by down-regulating miR-335 expression and mitigating insulin resistance and inflammation

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Otton, Rosemari [1] ; Bolin, Anaysa Paola [2] ; Ferreira, Leticia Torres [1] ; Marinovic, Marcelo Paradiso [1] ; Silva Rocha, Andrea Livia [3] ; Mori, Marcelo Alves [3]
Total Authors: 6
[1] Univ Cruzeiro Sul, CBS, Interdisciplinary Postgrad Program Hlth Sci, BR-03342000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Biomed Sci Inst, Dept Pharmacol, BR-05508000 Sao Paulo - Brazil
[3] Univ Estadual Campinas, Dept Biochem & Tissue Biol, BR-13083862 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF NUTRITIONAL BIOCHEMISTRY; v. 57, p. 170-179, JUL 2018.
Web of Science Citations: 11

Obesity leads to changes in miRNA expression in adipose tissue, and this modulation is linked to the pathophysiology of the disease. Green tea (GT) is a natural source of polyphenols that have been shown to confer health benefits, particularly preventing metabolic diseases. Here, we investigated if the beneficial effects of GT in obesity results from changes in the miRNA profile in white adipose tissue. GT treatment {[}500 mg/body weight (BW)/12 weeks] increased energy expenditure of high-fat diet-fed mice (16 weeks), leading to reduced weight gain, decreased adiposity, reduced inflammation and improved insulin sensitivity. These phenotypes were associated with a decrease in the expression of miR-335 in the adipose tissue. miR-335 was up-regulated by TNF-alpha in adipocytes and, in turn, down-regulated genes involved in insulin signaling and lipid metabolism. On the other hand, GT inhibited TNF-a effect. In conclusion, miR-335 serves as a link between inflammation and impaired metabolism in adipose tissue, providing an important mechanistic insight into the molecular basis underlying GT action during obesity. (C) 2018 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 13/22293-0 - Identification and validation of miRNA target genes in adipose tissue and liver of obese mice in response to treatment with green tea extract
Grantee:Rosemari Otton
Support Opportunities: Regular Research Grants
FAPESP's process: 15/01316-7 - Dicer, miRNAs and the control of mitochondrial function in the context of aging and caloric restriction
Grantee:Marcelo Alves da Silva Mori
Support Opportunities: Regular Research Grants