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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Viral immunogenicity determines epidemiological fitness in a cohort of DENV-1 infection in Brazil

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Author(s):
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Pinheiro, Tauyne Menegaldo [1] ; de Oliveira Mota, Manlio Tasso [1] ; Aranha Watanabe, Aripuana Sakurada [1, 2] ; Biselli-Perico, Joice Matos [1, 3] ; Drumond, Betania Paiva [4] ; Ribeiro, Milene Rocha [1] ; Vedovello, Danila [1] ; Araujo, Jr., Joao Pessoa [5] ; Paolucci Pimenta, Paulo Filemon [6] ; Chaves, Barbara Aparecida [6, 7, 8] ; Carneiro da Silva, Mayara Marques [9] ; Andrade Batista, Izabella Cristina [10] ; Papa, Michelle Premazzi [11] ; Meuren, Lana Monteiro [11] ; de Oliveira Lucas, Carolina Goncalves [11] ; Matassoli, Flavio Lemos [11] ; Vega Gonzales Gil, Laura Helena [9] ; Bozzi, Adriana [10] ; Calzavara-Silva, Carlos Eduardo [10] ; de Arruda, Luciana Barros [11] ; de Souza, Danielle da Gloria [12] ; Teixeira, Mauro Martins [13] ; Vasilakis, Nikos [14] ; Nogueira, Mauricio Lacerda [1]
Total Authors: 24
Affiliation:
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[1] Fac Med Sao Jose do Rio Preto, Lab Pesquisa Virol, Dept Doencas Dermatol Infecciosas & Parasitarias, Sao Jose Do Rio Preto, SP - Brazil
[2] Univ Fed Juiz de Fora, Lab Virol, Dept Parasitol Microbiol & Imunol, Juiz De Fora, MG - Brazil
[3] Univ Estadual Paulista, Dept Biol, Inst Biociencias Letras & Ciencias Exatas, Sao Jose Do Rio Preto, SP - Brazil
[4] Univ Fed Minas Gerais, Lab Virus, Inst Ciencias Biol, Belo Horizonte, MG - Brazil
[5] Univ Estadual Paulista Julio de Mesquita, Inst Biociencias, Lab Virol, Dept Microbiol & Imunol, Botucatu, SP - Brazil
[6] Fiocruz MS, Ctr Pesquisas Rene Rachou, Lab Entomol Med, Belo Horizonte, MG - Brazil
[7] Univ Estado Amazonas, Programa Posgrad Med Trop, Manaus, AM - Brazil
[8] Fundacao Med Trop Dr Heitor Vieira Dourado FMT HV, Manaus, AM - Brazil
[9] Fiocruz MS, Dept Virol, Ctr Pesquisas Aggeu Magalhaes, Recife, PE - Brazil
[10] Fiocruz MS, Ctr Pesquisas Rene Rachou, Lab Imunol Celular & Mol, Belo Horizonte, MG - Brazil
[11] Univ Fed Rio de Janeiro, Inst Microbiol Prof Paulo de Goes, Dept Virol, Lab Genet & Imunol Infeccoes Virais, Rio De Janeiro, RJ - Brazil
[12] Univ Fed Minas Gerais, Dept Microbiol, Inst Ciencias Biol, Belo Horizonte, MG - Brazil
[13] Univ Fed Minas Gerais, Dept Bioquim & Imunol, Inst Ciencias Biol, Lab Imunofarmacol, Belo Horizonte, MG - Brazil
[14] Univ Texas Med Branch, Ctr Trop Dis, Inst Human Infect & Immun, Dept Pathol, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 - USA
Total Affiliations: 14
Document type: Journal article
Source: PLoS Neglected Tropical Diseases; v. 12, n. 5 MAY 2018.
Web of Science Citations: 6
Abstract

The dynamics of dengue virus (DENV) circulation depends on serotype, genotype and lineage replacement and turnover. In Sao Jose do Rio Preto, Brazil, we observed that the L6 lineage of DENV-1 (genotype V) remained the dominant circulating lineage even after the introduction of the L1 lineage. We investigated viral fitness and immunogenicity of the L1 and L6 lineages and which factors interfered with the dynamics of DENV epidemics. The results showed a more efficient replicative fitness of L1 over L6 in mosquitoes and in human and non-human primate cell lines. Infections by the L6 lineage were associated with reduced antigenicity, weak B and T cell stimulation and weak host immune system interactions, which were associated with higher viremia. Our data, therefore, demonstrate that reduced viral immunogenicity and consequent greater viremia determined the increased epidemiological fitness of DENV-1 L6 lineage in Sao Jose do Rio Preto. (AU)

FAPESP's process: 15/22750-7 - Assessment of viral and epidemiological fitness differences between two lineages of Dengue serotype 1 co-circulating during 2010-2012 in São José do Rio Preto, SP
Grantee:Tauyne Menegaldo Pinheiro
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 13/21719-3 - Epidemiological study of dengue (serotypes1-4) in a cohort of São José do Rio Preto, São Paulo, Brazil, during 2014-2018
Grantee:Maurício Lacerda Nogueira
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 12/11733-6 - Biological and molecular characterization of dengue isolates, serotypes 1 and 2, in São José do Rio Preto city, SP, detected during 2006 to 2014 seasons
Grantee:Maurício Lacerda Nogueira
Support Opportunities: Regular Research Grants