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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cannabinoid Modulation of the Stressed Hippocampus

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Scarante, Franciele F. [1] ; Vila-Verde, Carla [1] ; Detoni, Vinicius L. [1] ; Ferreira-Junior, Nilson C. [1] ; Guimaraes, Francisco S. [1] ; Campos, Alline C. [1]
Total Authors: 6
[1] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Cannabinoid Res Inst, Dept Pharmacol, Sch Med Ribeirao Preto, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Web of Science Citations: 10

Exposure to stressful situations is one of the risk factors for the precipitation of several psychiatric disorders, including Major Depressive Disorder, Posttraumatic Stress Disorder and Schizophrenia. The hippocampal formation is a forebrain structure highly associated with emotional, learning and memory processes; being particularly vulnerable to stress. Exposure to stressful stimuli leads to neuroplastic changes and imbalance between inhibitory/excitatory networks. These changes have been associated with an impaired hippocampal function. Endocannabinoids (eCB) are one of the main systems controlling both excitatory and inhibitory neurotransmission, as well as neuroplasticity within the hippocampus. Cannabinoids receptors are highly expressed in the hippocampus, and several lines of evidence suggest that facilitation of cannabinoid signaling within this brain region prevents stress-induced behavioral changes. Also, chronic stress modulates hippocampal CB1 receptors expression and endocannabinoid levels. Moreover, cannabinoids participate in mechanisms related to synaptic plasticity and adult neurogenesis. Here, we discussed the main findings supporting the involvement of hippocampal cannabinoid neurotransmission in stress-induced behavioral and neuroplastic changes. (AU)

FAPESP's process: 15/05551-0 - Investigation of the involvement of endocannabinoid system on behavioral and plastic effects of antidepressant drugs
Grantee:Alline Cristina de Campos
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 12/17626-7 - Cellular and molecular mechanisms involved in the role of atypical neurotransmitters in neuropsychiatric disorders
Grantee:Francisco Silveira Guimaraes
Support type: Research Projects - Thematic Grants