| Full text | |
| Author(s): |
Soares, Jaine L. S.
[1]
;
Fernandes, Fernanda Pereira
[1]
;
Patente, Thiago Andrade
[2]
;
Monteiro, Maria B.
[3]
;
Parisi, Maria C.
[4]
;
Giannella-Neto, Daniel
[5]
;
Correa-Giannella, Maria L.
[3, 5]
;
Pontillo, Alessandra
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Lab Imunogenet, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Lab Imunol Tumores, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Fac Med, Lab Carboidratos & Radioimunoensaios LIM 18, Sao Paulo, SP - Brazil
[4] Univ Estadual Campinas, UNICAMP, Fac Med, Div Endocrinol, Dept Clin Med, Campinas, SP - Brazil
[5] Univ Nove Julho UNINOVE, Programa Posgrad Med, Campinas, SP - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Clinical Immunology; v. 187, p. 46-49, FEB 2018. |
| Web of Science Citations: | 6 |
| Abstract | |
Although inflammasome plays a well-known role in animal models of renal injury, limited studies in humans are available, and its participation in diabetic kidney disease (DKD) remains unknown. Aim of this study was to elucidate the contribution of inflammasome genetics in the development of DKD in type-1 diabetes (T1D). The association of functional variants in inflammasome genes with DKD was assessed by multivariate analysis in a retrospective and in a prospective cohort. NLRP1 rs2670660 and rs11651270 polymorphisms were significantly associated with a decrease risk to develop DKD (p(adj) < 0.01), and rs11651270 also with a lower risk of new renal events during follow-up (p(adj) = 0.01). Supporting these findings, diabetes metabolites (glycated albumin and high glucose) were able to modulate NLRP1 expression. This study is the first to suggest a protective role of NLRP1 in DKD, highlighting an emerging role of NLRP1 as a homeostatic factor against metabolic stress. (C) 2017 Elsevier Inc. All rights reserved. (AU) | |
| FAPESP's process: | 15/23395-6 - Immunogenetics of the inflammasome and translational study "from bed to bench and back": analysis of variations in inflammasome genes in monogenic and multifactorial autoinflammatory diseases for differential diagnosis and therapeutic applications |
| Grantee: | Alessandra Pontillo |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 09/09276-3 - Study of Polymorphisms in Genes Coding Antioxidant Enzymes and Glucose Transporters and the Susceptibility to Chronic Complications in Type 1 Diabetic Patients |
| Grantee: | Maria Lucia Cardillo Corrêa Giannella |
| Support Opportunities: | Regular Research Grants |