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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

S-nitrosoglutathione-containing chitosan nanoparticles dispersed in Pluronic F-127 hydrogel: Potential uses in topical applications

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Pelegrino, Milena T. [1, 2] ; de Araujo, Daniele R. [1, 2] ; Seabra, Amedea B. [1, 2]
Total Authors: 3
[1] Fed Univ ABC, Ctr Nat & Human Sci, Av Estados 5001, BR-09210580 Santo Andre, SP - Brazil
[2] Fed Univ ABC UFABC, Nanomed Res Unit NANOMED, Santo Andre, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Web of Science Citations: 7

The aim of this study was to prepare nitric oxide (NO) releasing nanoparticle/hydrogel with potential uses in topical applications. NO is a signaling molecule in skin. It controls the dermal blood flow, skin defense, and tissue repair. There is an interest for designing topical formulations that release NO/NO donors directly at the desired application site. S-nitrosoglutathione (GSNO), a NO donor, was incorporated into chitosan nanoparticles (CS NPs) (hydrodynamic size of 112.2 +/- 2.22 nm). Free GSNO or GSNO-containing CS NPs were incorporated in Pluronic F-127 (PL) hydrogels. The purpose of this study was to combine the advantages of CS NPs (as a drug delivery system with mucoadhesive properties) and a PL hydrogel, which permits a prolonged contact time for the NO donor on the mucosal/skin surfaces. Rheological measurements were performed to determine the sol-gel transition temperature, the rheological parameters, and the viscosity. The polymeric matrices spontaneously released free NO. GSNO diffusion from the polymeric matrices was evaluated using a diffusion system. The results indicate that the incorporation of GSNO-CS NPs into a PL hydrogel may find important dermatological applications due to their mechanical properties and their ability to release therapeutic and sustained amounts of NO at the desired application site. (AU)

FAPESP's process: 16/10347-6 - S-nitrosothiol containing nanoparticles: Synthesis, characterization, cytotoxicity and applications
Grantee:Amedea Barozzi Seabra
Support Opportunities: Regular Research Grants
FAPESP's process: 15/00393-8 - Nitric oxide releasing polymeric nanoparticles for topical applications
Grantee:Milena Trevisan Pelegrino
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 14/13913-7 - Preparation, characterization and biological evaluations of mono and bimetallic nanoparticles systems
Grantee:Paula Silvia Haddad Ferreira
Support Opportunities: Regular Research Grants