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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Molecular mechanisms of detection and discrimination of dynamic signals

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Antunes, G. [1] ; Roque, A. C. [1] ; Simoes-de-Souza, F. M. [2]
Total Authors: 3
[1] Univ Sao Paulo, Dept Phys, Lab Neural Syst SisNe, Ribeirao Preto, SP - Brazil
[2] Fed Univ ABC, Ctr Math Computat & Cognit, Sao Bernardo Do Campo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 8, FEB 6 2018.
Web of Science Citations: 1

Many molecules decode not only the concentration of cellular signals, but also their temporal dynamics. However, little is known about the mechanisms that underlie the detection and discrimination of dynamic signals. We used computational modelling of the interaction of a ligand with multiple targets to investigate how kinetic and thermodynamic parameters regulate their capabilities to respond to dynamic signals. Our results demonstrated that the detection and discrimination of temporal features of signal inputs occur for reactions proceeding outside mass-action equilibrium. For these reactions, thermodynamic parameters such as affinity do not predict their outcomes. Additionally, we showed that, at non-equilibrium, the association rate constants determine the amount of product formed in reversible reactions. In contrast, the dissociation rate constants regulate the time interval required for reversible reactions to achieve equilibrium and, consequently, control their ability to detect and discriminate dynamic features of cellular signals. (AU)

FAPESP's process: 14/08481-0 - Computational modeling of the postsynaptic mechanisms of the dopaminergic and glutamatergic integration in a hippocampal dendritic spine in health and pathological conditions
Grantee:Gabriela Antunes
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/18825-4 - Computing language with mirror neurons
Grantee:Fábio Marques Simões de Souza
Support Opportunities: Research Grants - Research Partnership for Technological Innovation - PITE
FAPESP's process: 15/50122-0 - Dynamic phenomena in complex networks: basics and applications
Grantee:Elbert Einstein Nehrer Macau
Support Opportunities: Research Projects - Thematic Grants