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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Understanding the Role of Intrinsic Disorder of Viral Proteins in the Oncogenicity of Different Types of HPV

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Tamarozzi, Elvira Regina [1] ; Giuliatti, Silvana [1]
Total Authors: 2
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Genet, BR-14049900 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Web of Science Citations: 5

Intrinsic disorder is very important in the biological function of several proteins, and is directly linked to their foldability during interaction with their targets. There is a close relationship between the intrinsically disordered proteins and the process of carcinogenesis involving viral pathogens. Among these pathogens, we have highlighted the human papillomavirus (HPV) in this study. HPV is currently among the most common sexually transmitted infections, besides being the cause of several types of cancer. HPVs are divided into two groups, called high- and low-risk, based on their oncogenic potential. The high-risk HPV E6 protein has been the target of much research, in seeking treatments against HPV, due to its direct involvement in the process of cell cycle control. To understand the role of intrinsic disorder of the viral proteins in the oncogenic potential of different HPV types, the structural characteristics of intrinsically disordered regions of high and low-risk HPV E6 proteins were analyzed. In silico analyses of primary sequences, prediction of tertiary structures, and analyses of molecular dynamics allowed the observation of the behavior of such disordered regions in these proteins, thereby proving a direct relationship of structural variation with the degree of oncogenicity of HPVs. The results obtained may contribute to the development of new therapies, targeting the E6 oncoprotein, for the treatment of HPV-associated diseases. (AU)

FAPESP's process: 13/21096-6 - Intrinsic disorder analysis on the E6 protein from cervical cancer high- and low-risk papilloma virus (HPV)
Grantee:Silvana Giuliatti
Support Opportunities: Regular Research Grants
FAPESP's process: 15/04606-6 - Modeling and analysis in silico of European variants of the E6 protein of human papillomavirus type 16
Grantee:Elvira Regina Tamarozzi
Support Opportunities: Scholarships in Brazil - Master