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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Long-Term Impact of High Levels of Alpha-Melanocyte-Stimulating Hormone in Energy Balance Among Obese Adolescents

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Pelissari Kravchychyn, Ana Claudia [1] ; da Silveira Campos, Raquel Munhoz [2] ; Corgosinho, Flavia Campos [3] ; Landi Masquio, Deborah Cristina [4] ; de Castro Ferreira Vicente, Sofia Emanuelle [1] ; Martins Ferreira, Yasmin Alaby [1] ; Silva, Patricia Leao [3] ; Ganen, Aline de Piano [4] ; Oyama, Lila Missae [1] ; Tock, Lian [5] ; de Mello, Marco Tulio [6] ; Tufik, Sergio [1] ; Damaso, Ana Raimunda [1]
Total Authors: 13
[1] Univ Fed Sao Paulo, Sao Paulo - Brazil
[2] Univ Fed Sao Carlos, Sao Paulo - Brazil
[3] Univ Fed Goias, Goiania, Go - Brazil
[4] Sao Camilo Univ Ctr, Sao Paulo - Brazil
[5] Weight Sci, Sao Paulo - Brazil
[6] Univ Fed Minas Gerais, Belo Horizonte, MG - Brazil
Total Affiliations: 6
Document type: Journal article
Source: ANNALS OF NUTRITION AND METABOLISM; v. 72, n. 4, p. 279-286, 2018.
Web of Science Citations: 0

Background: Deregulation of orexigenic and anorexigenic pathways occurs among adolescents with obesity. Alphamelanocyte-stimulating hormone (alpha-MSH) is a key catabolic mediator of energy homeostasis and an important anorexigenic neuropeptide in the control of energy balance and thermogenesis. However, it was not well explored if alpha-MSH can modulate long-term weight loss therapy responses in a dependent manner according to its concentration. Our hypothesis is that a high alpha-MSH concentration at baseline promotes better modulation of anorexigenic/orexigenic pathways in obese adolescents. Methods: One hundred ten post-pubertal obese adolescents (body mass index >95th percentile) were submitted to 1 year of interdisciplinary therapy (clinical, nutritional, psychological, physical exercise, and physiotherapy support). Body composition and plasma levels of a-MSH, neuropeptide Y (NPY), melanin-concentrating hormone, and agouti-related peptide (AgRP) were measured before and after therapy. The volunteers were grouped on the basis of Tertiles of alpha-MSH concentration: Low (<0.75 ng/mL), Medium (<= 0.76 to >= 1.57 ng/mL), and High (> 1.57 ng/mL). Significance was set as p < 0.05. Results: The treatment promoted a significant improvement in body adiposity and fat free mass for all groups. It is important to note that only in the high alpha-MSH group, a significant increase of the alpha-MSH/NPY ratio and decrease NPY/AgRP ratio post treatment were observed. Conclusion: The high alpha-MSH concentration promotes better modulation of anorexigenic/orexigenic pathways in obese adolescents following long-term weight loss therapy and this is important in clinical practice. (C) 2018 S. Karger AG, Basel (AU)

FAPESP's process: 17/07372-1 - New frontiers in the fight against obesity: digital health education as supporting in the interdisciplinary clinical process
Grantee:Ana Raimunda Dâmaso
Support type: Regular Research Grants
FAPESP's process: 13/19046-0 - Phototherapy and Physical Exercise: potential effects on the role of irisin and factores anorexigen and orexigen
Grantee:Marcela Sene Fiorese
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/08522-6 - New therapeutic perspectives in obesity
Grantee:Ana Raimunda Dâmaso
Support type: Regular Research Grants