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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antimicrobial sonodynamic and photodynamic therapies against Candida albicans

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Alves, Fernanda [1] ; Pavarina, Ana Claudia [1] ; de Oliveira Mima, Ewerton Garcia [1] ; McHale, Anthony P. [2] ; Callan, John Francis [2]
Total Authors: 5
[1] Sao Paulo State Univ Unesp, Sch Dent, Dept Dent Mat & Prosthodont, Araraquara - Brazil
[2] Ulster Univ, Fac Life & Hlth Sci, Sch Pharm & Pharmaceut Sci, Coleraine, Londonderry - North Ireland
Total Affiliations: 2
Document type: Journal article
Source: BIOFOULING; v. 34, n. 4, p. 357-367, 2018.
Web of Science Citations: 4

Candida albicans biofilms exhibit unique characteristics and are highly resistant to antifungal agents. Antimicrobial photodynamic therapy (aPDT) is an alternative treatment limited to treating superficial infections due to the poor light penetration. In this manuscript, the antifungal properties of sonodynamic therapy (SDT) were assessed. SDT uses ultrasound instead of light, enabling the treatment of deeper infections. Planktonic cells and biofilms of C. albicans were treated with aPDT or SDT, in addition to combined aPDT/SDT, with cell survival determined using colony forming units. The total biomass and structural integrity of the biofilms were also investigated. The results demonstrated that while individual aPDT or SDT eradicated suspensions, they had little impact on biofilms. However, combined aPDT/SDT significantly reduced the viability and total biomass of biofilms. Microscopic images revealed that biofilms treated with aPDT/SDT were thinner and comprised mainly of dead cells. These results highlight the potential of combined aPDT/SDT for the inactivation of C. albicans biofilms. (AU)

FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 14/01262-1 - Clinical evaluation of the Photodynamic Therapy efficacy, mediated by Photodithazine®,in the treatment of denture stomatitis.
Grantee:Fernanda Alves Dias de Sousa
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 16/00190-2 - Effects of photodynamic and sonodynamic therapies on the extracellular matrix of Candida albicans biofilm
Grantee:Fernanda Alves Dias de Sousa
Support Opportunities: Scholarships abroad - Research Internship - Doctorate