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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hypertension induces additional cardiometabolic impairments and attenuates aerobic exercise training adaptations in fructose-fed ovariectomized rats

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Author(s):
Brito-Monzani, Janaina de O. [1] ; Sanches, Iris Callado [2] ; Bernardes, Nathalia [3] ; Ponciano, Katia [2] ; Moraes-Silva, Ivana C. [4] ; Irigoyen, Maria-Claudia [4] ; Llesuy, Susana [5] ; De Angelis, Katia [3]
Total Authors: 8
Affiliation:
[1] Univ Fed Maranhao, Lab Cardiovasc Adaptat Exercise LACORE, Sao Luis - Brazil
[2] Univ Sao Judas Tadeu, Sao Paulo - Brazil
[3] Univ Nove Julho UNINOVE, Lab Translat Physiol, Sci Rehabil Program, Rua Vergueiro 235-249-2 Subsolo Mestrado, BR-01504001 Sao Paulo - Brazil
[4] Univ Sao Paulo, Med Sch, Heart Inst InCor, Hypertens Unit, Sao Paulo - Brazil
[5] Univ Buenos Aires, Fac Farm & Bioquim, Buenos Aires, DF - Argentina
Total Affiliations: 5
Document type: Journal article
Source: HYPERTENSION RESEARCH; v. 41, n. 2, p. 88-95, FEB 2018.
Web of Science Citations: 1
Abstract

We tested whether hypertension favors the development of additional cardiometabolic changes in fructose-fed ovariectomized rats and how it affects aerobic exercise training (ET) effects. All rats received fructose in drinking water (10%) beginning at weaning, were ovariectomized at 10 weeks of age and divided into the normotensive sedentary (NFOS) and trained (NFOT) and hypertensive sedentary (HFOS) and trained (HFOT) groups. ET was performed on a treadmill. Arterial pressure (AP) was directly recorded; heart rate and AP variabilities were analyzed. Lipoperoxidation (LPO) and antioxidant enzyme levels were measured in the left ventricle. In addition to increased AP levels, when compared with the NFOS group, the hypertensive groups had resting tachycardia, a reduction of 29% in the pulse interval variance (VAR-PI), 19% in RMSSD (root mean square of successive differences, a cardiac parasympathetic index) and 53% in the a-index (spontaneous baroreflex), while the systolic AP variance (VAR-SAP) and its low-frequency band (LF-SAP) were sharply increased. ET did not alter AP levels. Even in the presence of hypertension, ET induced resting bradycardia, decreases of 33% in VAR-SAP and 49% in LF-SAP, and an increase of more than 60% in VAR-PI and the a-index. However, some of these parameters were still impaired relative to those of normotensive rats. LPO was reduced and catalase was increased in both trained groups, with no difference between the normotensive and hypertensive groups. Negative correlations were obtained between LPO and RMSSD (r=-0.60, Po0.05) and a-index (r=-0.63, Po0.05). In conclusion, hypertension augmented the dysfunctions in fructose-fed ovariectomized rats and attenuated metabolic aerobic ET benefits. These changes may be related to cardiovascular autonomic and oxidative stress alterations. (AU)

FAPESP's process: 12/20141-5 - Effects of aerobic,resistance or combined exercise training in experimental models of cardiometabolic disorders associated with ovarian hormone deprivation
Grantee:Kátia de Angelis Lobo D Avila
Support type: Regular Research Grants
FAPESP's process: 10/17188-4 - Dysfunction associated mechanisms to a menopause and syndrome metabolic experimental model: role of aerobic and resistance exercise training
Grantee:Janaina de Oliveira Brito
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/11223-6 - Time course of neuroimmune changes induced by chronic fructose consumption in normotensive and hypertensive rats: role of aerobic exercise training
Grantee:Kátia de Angelis Lobo D Avila
Support type: Regular Research Grants