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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Current contribution of diffusion tensor imaging in the evaluation of diffuse axonal injury

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Author(s):
Grassi, Daphine Centola [1] ; da Conceicao, David Macedo [1] ; Leite, Claudia da Costa [1] ; Andrade, Celi Santos [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Fac Med, Dept Radiol, Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Arquivos de Neuro-Psiquiatria; v. 76, n. 3, p. 189-199, MAR 2018.
Web of Science Citations: 4
Abstract

Traumatic brain injury (TBI) is the number one cause of death and morbidity among young adults. Moreover, survivors are frequently left with functional disabilities during the most productive years of their lives. One main aspect of TBI pathology is diffuse axonal injury, which is increasingly recognized due to its presence in 40% to 50% of all cases that require hospital admission. Diffuse axonal injury is defined as widespread axonal damage and is characterized by complete axotomy and secondary reactions due to overall axonopathy. These changes can be seen in neuroimaging studies as hemorrhagic focal areas and diffuse edema. However, the diffuse axonal injury findings are frequently under-recognized in conventional neuroimaging studies. In such scenarios, diffuse tensor imaging (DTI) plays an important role because it provides further information on white matter integrity that is not obtained with standard magnetic resonance imaging sequences. Extensive reviews concerning the physics of DTI and its use in the context of TBI patients have been published, but these issues are still hazy for many allied-health professionals. Herein, we aim to review the current contribution of diverse state-of-the-art DTI analytical methods to the understanding of diffuse axonal injury pathophysiology and prognosis, to serve as a quick reference for those interested in planning new studies and who are involved in the care of TBI victims. For this purpose, a comprehensive search in Pubmed was performed using the following keywords: ``traumatic brain injury{''}, ``diffuse axonal injury{''}, and ``diffusion tensor imaging{''}. (AU)

FAPESP's process: 15/18136-1 - Longitudinal multimodal analysis of diffusion tensor imaging of the brain in patients with moderate to severe traumatic diffuse axonal injury
Grantee:Celi Santos Andrade
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 17/17065-9 - Longitudinal analysis of diffusion tensor imaging of the brain in patients with moderate to severe traumatic diffuse axonal injury
Grantee:Daphine Centola Grassi
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 16/05547-6 - Longitudinal multimodal analysis of diffusion tensor imaging of the brain in patients with moderate to severe traumatic diffuse axonal injury
Grantee:Celi Santos Andrade
Support Opportunities: Scholarships in Brazil - Young Researchers