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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of menopausal status on the main contributors of muscle quality

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Carvalho, L. P. [1, 2, 3] ; Borghi-Silva, A. [1] ; Dupontgand, S. [2, 3] ; Di Thommazo-Luporini, L. [1] ; Mendes, R. G. [1] ; Aubertin-Leheudre, M. [2, 3]
Total Authors: 6
[1] Univ Sao Carlos, Dept Phys Therapy, Sao Carlos, SP - Brazil
[2] Univ Quebec Montreal, Dept Phys Act Sci, Montreal, PQ - Canada
[3] Ctr Rech Inst Univ Geriatrie Montreal, Montreal, PQ - Canada
Total Affiliations: 3
Document type: Journal article
Source: CLIMACTERIC; v. 21, n. 3, p. 298-302, 2018.
Web of Science Citations: 0

Background: Muscle quality is a strong independent predictor of physical function. Body mass and fatness, muscle mass and cardiorespiratory fitness are known to influence muscle quality.Objective: To identify the contributors of muscle quality in young and postmenopausal women and whether hormone replacement therapy (HT) could influence this relationship at the age of menopause.Methods: Fifty-four postmenopausal women, 27 not on HT (PMW) and 27 on HT (PMW-HT), and 33 young women (YW) were evaluated for (1) body composition (body mass index, BMI), total fat mass (FM, %), appendicular lean mass (ALM, in kg and %), and appendicular skeletal mass index (ASMI=ALM/height(2) in kg/m(2)); (2) absolute peak oxygen uptake (VO2peak, in ml/min) and relative peak oxygen uptake (VO2peakRel in ml/kg/min); and (3) absolute isometric knee extension strength (iKES in kg) and relative isometric knee extension strength (iKES/BMI and iKES/ALM).Results: YW, PMW and PMW-HT had similar BMI (32.110.2, 27.3 +/- 4.7 and 26.7 +/- 4kg/m(2)) and FM (39.8 +/- 10.0, 39.8 +/- 7.3 and 39.9 +/- 7.1%), respectively. Correlations were found between iKES/BMI index and FM (r=-0.52), ALM (r=0.32) and VO2peak (r=0.31). Regression analysis demonstrated that, in YW, total amount of variance in iKES/BMI was mostly explained by ALM (42%), whereas, in PMW and PMW-HT, it was cumulatively explained by FM along with VO2peakRel (34 and 46%, respectively).Conclusion: The main contributors of muscle quality differ between young and postmenopausal women and HT does not seem to influence this relationship. (AU)

FAPESP's process: 13/15681-3 - Relationship between peripheral muscle structure and function, inflammation and autonomic regulation in exercise capacity in obese adults
Grantee:Lívia Pinheiro Carvalho
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 15/12751-6 - Effects of a combined intervention of a nutritional supplementation associated with a walking exercise training to improve health in sarcopenic-obese elderly men: its influence on fatness and fitness
Grantee:Lívia Pinheiro Carvalho
Support type: Scholarships abroad - Research Internship - Doctorate (Direct)