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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Role of Exosomal MicroRnAs and myomiRs in the Development of Cancer Cachexia-Associated Muscle Wasting

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Marinho, Rodolfo [1] ; Alcantara, Paulo S. M. [2] ; Ottoch, Jose P. [2] ; Seelaender, Marilia [1, 2]
Total Authors: 4
[1] Univ Sao Paulo, Inst Biomed Sci, Canc Metab Res Grp, Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Clin Surg, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: FRONTIERS IN NUTRITION; v. 4, JAN 9 2018.
Web of Science Citations: 11

Cachexia is a complex metabolic syndrome that promotes great weight loss, with marked muscle mass wasting. In the last years, many efforts have been directed to improve the understanding of the mechanisms involved in the disease. This syndrome is present in up to 80% of cancer patients and, despite its clinical relevance, is underdiagnosed. The orchestration of the molecular and biochemical disruptions observed in cachexia is paralleled by inflammation and the communication among the different body compartments, including the tumor and the skeletal muscle, is still not completely described. One of the mechanisms that may be involved in the transduction of the inflammatory signals and the activation of catabolic status in muscle is the participation of exosomes containing microRNAs (miRNAs) and muscle-specific miRNAs (myomiRs). Exosomes are nanovesicles, measuring from 30 to 100 mu m, and able to carry miRNAs in the circulation, promoting cell-cell and tissue-tissue communication in an autocrine, paracrine, and endocrine manner. miRNAs transported in exosomes are preserved from degradation, while these nanoparticles deliver the cargo to specific cell targets, making communication more efficient. Several miRNAs are known to modulate inflammatory pathways, to induce metastasis, to mediate cancer aggressiveness and even to participate in the regulation of protein synthesis and degradation pathways in the skeletal muscle. The aim of this mini-review is to describe the present knowledge about the role of exosomal miRNAs and myomiRs in the induction of muscle mass wasting in cancer cachexia state and to explain which transcription factors, proteins, and pathways are regulated by these molecules. (AU)

FAPESP's process: 12/50079-0 - Systemic inflammation in cachectic cancer patients: mechanisms and therapeutical strategies, a translational medicine approach
Grantee:Marilia Cerqueira Leite Seelaender
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 16/19639-0 - Role of tumor-derived microRNAs in inducing muscle mass loss in patients with Cancer Cachexia
Grantee:Rodolfo Marinho
Support Opportunities: Scholarships in Brazil - Post-Doctoral