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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Neospora caninum bioassay in gerbils using placental tissues from naturally infected goats

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Costa, R. C. [1, 2] ; Mesquita, L. P. [2] ; Nunes, M. V. L. [1] ; Oliveira, I. M. [1] ; Oliveira, L. F. S. [1] ; Souza, Alinne R. [1] ; Maiorka, P. C. [2] ; Varaschin, M. S. [1]
Total Authors: 8
[1] Univ Fed Lavras, Dept Vet Med, Lavras - Brazil
[2] Univ Sao Paulo, Dept Pathol, Av Prof Orlando Marques de Paiva 87, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Veterinary Parasitology; v. 249, p. 70-73, JAN 15 2018.
Web of Science Citations: 2

Neospora caninum is one of the main agents that causes abortions in cattle worldwide. However, little is known about the pathogenesis of neosporosis in small ruminants, especially goats. Gerbils (Meriones unguiculatus) have been used as a model for neosporosis, and this species is highly susceptible to infection by bovine N. caninum strains. The present study aimed to evaluate the susceptibility of gerbils to a N. caninum isolate from goats. The placentas were obtained from naturally infected goats, that presented with mild to severe lymphoplasmacytic and histiocytic infiltrate, foci of necrosis, calcification and protozoan-like structures. Immunosuppressed gerbils bioassayed with N. caninum-infected placental tissues showed severe neurological signs. Microscopic lesions in these gerbils were characterized by encephalitis, myocarditis, myositis and pancreatitis. These lesions were often associated with a small to moderate number of N. caninum tachyzoites, confirmed by immunohistochemistry and PCR. This is the first report showing that goat N. caninum strains could infect immunocompetent gerbils and cause severe lesions and clinical signs in immunosuppressed gerbils. (AU)

FAPESP's process: 16/24856-0 - Characterization of inflammatory response in the central nervous system in mouse models of viral and protozoan infection
Grantee:Paulo César Maiorka
Support Opportunities: Regular Research Grants
FAPESP's process: 16/05010-2 - Isolation and pathogenicity evaluation of a new Neospora caninum strain from naturally infected goats
Grantee:Rafael Carneiro Costa
Support Opportunities: Scholarships in Brazil - Doctorate