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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Polymorphisms in HLA-C and KIR alleles are not associated with HAM/TSP risk in HTLV-1-infected subjects

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Author(s):
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Assone, Tatiane [1, 2] ; Malta, Fernanda M. [1, 3] ; Bakkour, Sonia [4] ; Montalvo, Leilani [4] ; Paiva, Arthur M. [1, 2] ; Smid, Jerusa [5] ; Penalva de Oliveira, Augusto Cesar [5] ; Goncalves, Fernanda de Toledo [6] ; Luiz, Olinda do Carmo [7] ; Fonseca, Luiz Augusto M. [7] ; Norris, Philip J. [4, 8] ; Casseb, Jorge [1, 2]
Total Authors: 12
Affiliation:
[1] Univ Sao Paulo, Inst Trop Med Sao Paulo, Sao Paulo - Brazil
[2] Univ Sao Paulo, Med Sch, Dept Dermatol, Lab Dermatol & Immunodeficiencies, Sao Paulo - Brazil
[3] Univ Sao Paulo, Med Sch, Lab Gastroenterol & Trop Hepatol, Dept Gastroenterol, Sao Paulo - Brazil
[4] Blood Syst Res Inst, San Francisco, CA - USA
[5] Inst Infect Dis Emilio Ribas IIER, Sao Paulo - Brazil
[6] Univ Sao Paulo, Med Sch, Lab Immunohematol & Forens Hematol LIM40, Dept Forens Med Med Eth Social Med & Work, Sao Paulo - Brazil
[7] Univ Sao Paulo, Med Sch LIM 38, Dept Prevent Med, Sao Paulo - Brazil
[8] Univ Calif San Francisco, San Francisco, CA 94143 - USA
Total Affiliations: 8
Document type: Journal article
Source: VIRUS RESEARCH; v. 244, n. SI, p. 71-74, JAN 15 2018.
Web of Science Citations: 2
Abstract

Introduction: Several genetic polymorphisms may be related to susceptibility or resistance to viral disease outcomes. Immunological or genetic factors may act as major triggers of the immune pathogenesis of HAM/TSP. This study investigated the association of immune related genetic polymorphisms with viral and immunological markers. Methods: 247 HTLV-1-infected volunteers, drawn from a larger group of HTLV-infected subjects followed at the Institute of Infectious Diseases ``Emilio Ribas{''} (IIER) for up to 19 years, participated in this study, which ran from June 2011 to July 2016. The subjects were classified according to their neurological status into two groups: Group 1 (160 asymptomatic individuals) and Group 2 (87 HAM/TSP patients). Samples were tested for spontaneous lymphocyte proliferation (LPA) and HTLV-1 proviral load (PVL) and for IFN-lambda 4, HLA-C and KIR genotypes using qPCR. Results: We found associations between LPA (p = 0.0001) with HAM/TSP and confirmed the IFN-lambda 4 polymorphism rs8099917, allele GG, as a protective factor using a recessive model (OR = 3.22, CI = 1.10-9.47). Polymorphisms in HLA-C and KIR alleles were not associated with risk of developing HAM/TSP. Conclusion: We demonstrated that age, LPA and an IFN-lambda 4 polymorphism were associated with progression to HAM/TSP. Understanding HAM/TSP pathogenesis can provide important markers of prognostic value for clinical management, and contribute to the discovery of new therapeutic interventions in the future. (AU)

FAPESP's process: 14/22827-7 - Prevalence and incidence of early central nervous system disturbance in HTLV-1-infected subjects in Brazil
Grantee:Jorge Simão do Rosário Casseb
Support Opportunities: Regular Research Grants
FAPESP's process: 12/23397-0 - Determination of IL28B polymorphism profile in patients co-infected with Chronic Hepatitis C (HCV) virus and human T-lymphotropic type 1 (HTLV-1)
Grantee:Jorge Simão do Rosário Casseb
Support Opportunities: Regular Research Grants