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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Role of Beta-adrenergic Receptors and Sirtuin Signaling in the Heart During Aging, Heart Failure, and Adaptation to Stress

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Spadari, Regina Celia [1, 2] ; Cavadas, Claudia [3, 4] ; Saturi de Carvalho, Ana Elisa T. [1] ; Ortolani, Daniela [1, 5] ; de Moura, Andre Luiz [1] ; Vassalo, Paula Frizera [5, 6]
Total Authors: 6
[1] Univ Fed Sao Paulo UNIFESP, Lab Stress Biol, Dept Biosci, Campus Baixada Santista, Santos - Brazil
[2] UNIFESP, Dept Biociencias, Campus Baixada Santista, Rua Silva Jardim 136, BR-11015020 Santos, SP - Brazil
[3] Univ Coimbra, Ctr Neurosci & Cell Biol CNC, Coimbra - Portugal
[4] Univ Coimbra, Sch Pharm, Coimbra - Portugal
[5] Univ Fed Espirito Santo, Dept Physiol Sci, HUCAM, Vitoria - Brazil
[6] Univ Fed Espirito Santo, Univ Hosp Cassiano Antonio de Moraes, HUCAM, Vitoria - Brazil
Total Affiliations: 6
Document type: Review article
Source: Cellular and Molecular Neurobiology; v. 38, n. 1, SI, p. 109-120, JAN 2018.
Web of Science Citations: 9

In the heart, catecholamine effects occur by activation of beta-adrenergic receptors (beta-ARs), mainly the beta 1 (beta(1)-AR) and beta 2 (beta(2)-AR) subtypes, both of which couple to the Gs protein that activates the adenylyl cyclase signaling pathway. The beta(2)-ARs can also couple to the Gi protein that counterbalances the effect of the Gs protein on cyclic adenosine monophosphate production and activates the phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway. In several cardiovascular disorders, including heart failure, as well as in aging and in animal models of environmental stress, a reduction in the beta(1)/beta(2)-AR ratio and activation of the beta(2)-AR-Gi-PI3K-Akt signaling pathway have been observed. Recent studies have shown that sirtuins modulate certain organic processes, including the cellular stress response, through activation of the PI3K-Akt signaling pathway and of downstream molecules such as p53, Akt, HIF1-alpha, and nuclear factor-kappa B. In the heart, SIRT1, SIRT3, and beta(2)-ARs are crucial to the regulation of the cardiomyocyte energy metabolism, oxidative stress, reactive oxygen species production, and autophagy. SIRT1 and the beta(2)-AR-Gi complex also control signaling pathways of cell survival and death. Here, we review the role played by beta(2)-ARs and sirtuins during aging, heart failure, and adaptation to stress, focusing on the putative interplay between the two. That relationship, if proven, merits further investigation in the context of cardiac function and dysfunction. (AU)

FAPESP's process: 16/20777-8 - The influence of sirtuins on beta 2 adrenergic pathway in heart of rats submitted to stress
Grantee:Regina Celia Spadari
Support Opportunities: Regular Research Grants
FAPESP's process: 12/21990-6 - Role of nitric oxide synthases and beta-adrenoceptors in cardiac tissue of rats submitted to stress with access to Comfort food
Grantee:Regina Celia Spadari
Support Opportunities: Regular Research Grants