Chronic Lithium Treatment Increases Telomere Lengt... - BV FAPESP
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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chronic Lithium Treatment Increases Telomere Length in Parietal Cortex and Hippocampus of Triple-Transgenic Alzheimer's Disease Mice

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Author(s):
Cardillo, Giancarlo de Mattos [1] ; Rodrigues De-Paula, Vanessa de Jesus [1, 2] ; Ikenaga, Eliza Hiromi [1] ; Costa, Luciana Rodrigues [1] ; Catanozi, Sergio [3] ; Schaeffer, Evelin Lisete [1] ; Gattaz, Wagner Farid [1] ; Kerr, Daniel Shikanai [1, 4] ; Forlenza, Orestes Vicente [1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Fac Med, Lab Neurosci LIM 27, Inst Psiquiatria, Hosp Clin HCFMUSP, Rua Dr Ovidio Pires de Campos 785, BR-05403010 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, Lab Psysbio LIM 23, Inst Psiquiatria, Hosp Clin HCFMUSP, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Fac Med, Lipids Lab LIM 10, Endocrinol & Metab Div, Hosp Clin HCFMUSP, Sao Paulo, SP - Brazil
[4] Inst Fed Educ Ciencia & Tecnol Catarinense, Campus Camboriu, Camboriu, SC - Brazil
Total Affiliations: 4
Document type: Journal article
Source: JOURNAL OF ALZHEIMER'S DISEASE; v. 63, n. 1, p. 93-101, 2018.
Web of Science Citations: 3
Abstract

Telomere length (TL) is a biomarker of cell aging, and its shortening has been linked to several age-related diseases. In Alzheimer's disease (AD), telomere shortening has been associated with neuroinflammation and oxidative stress. The majority of studies on TL in AD were based on leucocyte DNA, with little information about its status in the central nervous system. In addition to other neuroprotective effects, lithium has been implicated in the maintenance of TL. The present study aims to determine the effect of chronic lithium treatment on TL in different regions of the mouse brain, using a triple-transgenic mouse model (3xTg-AD). Eighteen transgenic and 22 wild-type (Wt) male mice were treated for eight months with chow containing 1.0 g (Li1) or 2.0 g (Li2) of lithium carbonate/kg, or standard chow (Li0). DNA was extracted from parietal cortex, hippocampus and olfactory epithelium and TL was quantified by real-time PCR. Chronic lithium treatment was associated with longer telomeres in the hippocampus (Li2, p = 0.0159) and in the parietal cortex (Li1, p = 0.0375) of 3xTg-AD compared to Wt. Our findings suggest that chronic lithium treatment does affect telomere maintenance, but the magnitude and nature of this effect depend on the working concentrations of lithium and characteristics of the tissue. This effect was observed when comparing 3xTg-AD with Wt mice, suggesting that the presence of AD pathology was required for the lithium modulation of TL. (AU)

FAPESP's process: 14/14211-6 - Telomere length in the central nervous system of a model of Alzheimer's Disease treated with lithium
Grantee:Giancarlo de Mattos Cardillo
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 09/52825-8 - Neurobiology of Alzheimer's disease: risk markers, prognosis and therapeutic response
Grantee:Wagner Farid Gattaz
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 16/01302-9 - Direct and indirect pathways of glycogen synthase kinase 3B inhibition by lithium in culture of neurons
Grantee:Vanessa de Jesus Rodrigues de Paula
Support Opportunities: Scholarships in Brazil - Post-Doctoral