Polvora, Tabata Larissa S.
Nobre, Atila Vinicius V.
Taba, Jr., Mario
de Macedo, Leandro Dorigan
Santana, Rodrigo Carvalho
Lourenco, Alan Grupioni
Motta, Ana Carolina F.
Total Authors: 9
 Univ Sao Paulo, Sch Dent, Dept Stomatol, Sao Paulo - Brazil
 Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Oral & Maxillofacial Surg & Periodontol, Ribeirao Preto - Brazil
 Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Dent Mat & Prosthesis, Ribeirao Preto - Brazil
 Univ Sao Paulo, Ribeirao Preto Med Sch, Div Dent & Stomatol, Clin Hosp, Ribeirao Preto - Brazil
 Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Ribeirao Preto - Brazil
 Univ Lyon, GIMAP, EA 3064, St Etienne - France
 Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Stomatol Publ Oral Hlth & Forens Dent, Ave Cafe S-N, BR-14040904 Ribeirao Preto - Brazil
Total Affiliations: 7
EXPERT REVIEW OF CLINICAL IMMUNOLOGY;
Web of Science Citations:
Introduction: Current studies show that, even in the era of antiretroviral therapies, HIV-1 infection is associated with more severe and frequent refractory chronic periodontitis.Areas covered: This review, based on a systematic analysis of the literature, intends to provide an update on factors that may be involved in the pathogenesis of periodontal disease in HIV-1-infected patients, including local immunosuppression, oral microbial factors, systemic inflammation, salivary markers, and the role of gingival tissue as a possible reservoir of HIV-1.Expert commentary: The therapeutic revolution of ART made HIV-1 infection a chronic controllable disease, reduced HIV-1 mortality rate, restored at least partially the immune response and dramatically increased life expectancy of HIV-1-infected patients. Despite all these positive aspects, chronic periodontitis assumes an important role in the HIV-1 infection status for activating systemic inflammation favoring viral replication and influencing HIV-1 status, and also acting as a possible reservoir of HIV-1. All these issues still need to be clarified and validated, but have important clinical implications that certainly will benefit the diagnosis and management of chronic periodontitis in HIV-1-infected patients, and also contributes to HIV-1 eradication. (AU)