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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Aerobic exercise training differentially affects ACE C- and N-domain activities in humans: Interactions with ACE I/D polymorphism and association with vascular reactivity

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Alves, Cleber Rene [1, 2, 3] ; Fernandes, Tiago [2] ; Lemos, Jr., Jose Ribeiro [1, 3] ; Magalhaes, Flavio de Castro [2, 4] ; Trombetta, Ivani Credidio [1] ; Alves, Guilherme Barreto [3] ; Alves da Mota, Gloria de Fatima [2] ; Dias, Rodrigo Goncalves [5] ; Pereira, Alexandre Costa [3] ; Krieger, Jose Eduardo [3] ; Negrao, Carlos Eduardo [2, 3] ; Oliveira, Edilamar Menezes [2]
Total Authors: 12
[1] Univ Nove Julho, UNINOVE, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Heart Inst Incor, Sch Med, Sao Paulo, SP - Brazil
[4] Fed Univ Jequitinhonha & Mucuri Valleys, Multictr Program Postgrad Physiol Sci, Diamantina, MG - Brazil
[5] Fed Univ Maranhao UFMA, Dept Phys Educ, Sao Luis - Brazil
Total Affiliations: 5
Document type: Journal article
Web of Science Citations: 1

Introduction: Previous studies have linked angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism (II, ID and DD) to physical performance. Moreover, ACE has two catalytic domains: NH2 (N) and COOH (C) with distinct functions, and their activity has been found to be modulated by ACE polymorphism. The aim of the present study is to investigate the effects of the interaction between aerobic exercise training (AET) and ACE I/D polymorphism on ACE N- and C-domain activities and vascular reactivity in humans. Materials and methods: A total of 315 pre-selected healthy males were genotyped for II, ID and DD genotypes. Fifty completed the full AET (II, n = 12; ID, n = 25; and DD, n = 13), performed in three 90-minute sessions weekly, in the four-month exercise protocol. Pre- and post-training resting heart rate (HR), peak O-2 consumption (VO2 peak), mean blood pressure (MBP), forearm vascular conduction (FVC), total circulating ACE and C- and N-domain activities were assessed. One-way ANOVA and two-way repeated-measures ANOVA were used. Results: In pre-training, all variables were similar among the three genotypes. In post-training, a similar increase in FVC (35%) was observed in the three genotypes. AET increased VO2 peak similarly in II, ID and DD (492 vs. 57 +/- 1; 48 +/- 1 vs. 56 +/- 3; and 48 +/- 5 vs. 58 +/- 2 ml/kg/min, respectively). Moreover, there were no changes in HR and MBP. The DD genotype was also associated with greater ACE and C-domain activities at pre- and post-training when compared to II. AET decreased similarly the total ACE and C-domain activities in all genotypes, while increasing the N-domain activity in the II and DD genotypes. However, interestingly, the measurements of N-domain activity after training indicate a greater activity than the other genotypes. These results suggest that the vasodilation in response to AET may be associated with the decrease in total ACE and C-domain activities, regardless of genotype, and that the increase in N-domain activity is dependent on the DD genotype. Conclusions: AET differentially affects the ACE C- and N-domain activities, and the N-domain activity is dependent on ACE polymorphism. (AU)

FAPESP's process: 10/50048-1 - Cellular and functional bases of exercise in cardiovascular diseases
Grantee:Carlos Eduardo Negrão
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 09/18370-3 - microRNA expression on normotensive rats heart submitted to different aerobic training and the potential to hypertension therapy.
Grantee:Edilamar Menezes de Oliveira
Support Opportunities: Regular Research Grants