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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Detection and genotyping of human papillomavirus (HPV) in HIV-infected women and its relationship with HPV/HIV co-infection

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Badial, Rodolfo Miglioli [1] ; Dias, Marina Carrara [1] ; Stuqui, Bruna [1] ; dos Santos Melli, Patricia Pereira [2] ; Quintana, Silvana Maria [3] ; do Bonfim, Caroline Measso [1] ; Cordeiro, Jose Antonio [4] ; Rabachini, Tatiana [5] ; Calmon, Marilia de Freitas [1] ; Scarin Provazzi, Paola Jocelan [1] ; Rahal, Paula [1]
Total Authors: 11
[1] Sao Paulo State Univ UNESP, Dept Biol, Sao Jose Do Rio Preto, SP - Brazil
[2] Hosp Ribeirao Preto, Sch Med HC FMRP, Dept Obstet & Gynecol, Sao Jose Do Rio Preto, SP - Brazil
[3] Univ Sao Paulo, Med Sch Ribeirao Preto, Dept Gynecol & Obstet, Sao Jose Do Rio Preto, SP - Brazil
[4] Fac Med Sao Jose do Rio Preto FAMERP, Dept Epidemiol & Publ Hlth, Sao Jose Do Rio Preto, SP - Brazil
[5] Univ Bern, Inst Pharmacol, Bern - Switzerland
Total Affiliations: 5
Document type: Journal article
Source: MEDICINE; v. 97, n. 14 APR 2018.
Web of Science Citations: 3

HPV have been identified as high-risk and low-risk, depending on their association with the development of cancer. HPV infections can be facilitated by co-infection with HIV. Here, we investigated HPV prevalence and genotypes and the risk factors affecting HPV/HIV co-infection. Forty HIV-positive patients had 80 cervical swab samples collected in 2 consecutive years. Polymerase chain reaction and DNA direct sequencing were used to perform HPV genotyping. Statistical analyses were performed regarding risk factors for HPV/HIV co-infection and the occurrence of cervical lesions. HPV DNA was detected in 59 samples (73.75%), and high-risk HPVs were predominant (59.3%). The most prevalent type was HPV56 (17%), followed by HPV16 (15.3%). Patient age did not affect the risk of cervical cancer (P=.84) or HPV prevalence in different years (P=.25/P=.63). CD4 count also did not affect the risk for cervical lesions in the tested samples (P=.15/P=.28). Although the HIV viral load was not correlated with an increase in cervical lesion detection in the first group of analyzed samples (P=.12), it did affect cervical cancer risk in the group of samples analyzed in the following year (P=.045). HIV-infected patients presented a high prevalence of HPV co-infection, and HPV16 and HPV56 were the most prevalent genotypes. Considering this, it is possible that immunodeficiency can contribute to increased susceptibility to HPV56 infection in HIV-infected patients. The association between HIV viral load and the lesions also confirmed the importance of monitoring HIV/HPV co-infected patients with high HIV viral loads. (AU)

FAPESP's process: 14/02064-9 - Analysis of the antiviral action of the curcumin natural compound associated with nanoparticles in HPV-16 positive and negative vulvar carcinoma cell lines
Grantee:Caroline Measso Do Bonfim
Support Opportunities: Scholarships in Brazil - Post-Doctorate