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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Epigenetic alterations are associated with monocyte immune dysfunctions in HIV-1 infection

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Espindola, Milena S. [1] ; Soares, Luana S. [1] ; Galvao-Lima, Leonardo J. [1] ; Zambuzi, Fabiana A. [1] ; Cacemiro, Maira C. [1] ; Brauer, Veronica S. [1] ; Marzocchi-Machado, Cleni M. [1] ; Gomes, Matheus de Souza [2] ; Amaral, Laurence R. [2] ; Martins-Filho, Olindo A. [3] ; Bollela, Valdes R. [4] ; Frantz, Fabiani G. [1]
Total Authors: 12
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Ribeirao Preto, SP - Brazil
[2] Univ Fed Uberlandia, Lab Bioinformat & Analises Mol INGEB FACOM, Patos De Minas, MG - Brazil
[3] Fiocruz MS, Ctr Pesquisas Rene Rachou, Lab Biomarcadores Diagnost & Monitoramento, Belo Horizonte, MG - Brazil
[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 8, APR 3 2018.
Web of Science Citations: 5

Monocytes are key cells in the immune dysregulation observed during human immunodeficiency virus (HIV) infection. The events that take place specifically in monocytes may contribute to the systemic immune dysfunction characterized by excessive immune activation in infected individuals, which directly correlates with pathogenesis and progression of the disease. Here, we investigated the immune dysfunction in monocytes from untreated and treated HIV + patients and associated these findings with epigenetic changes. Monocytes from HIV patients showed dysfunctional ability of phagocytosis and killing, and exhibited dysregulated cytokines and reactive oxygen species production after M. tuberculosis challenge in vitro. In addition, we showed that the expression of enzymes responsible for epigenetic changes was altered during HIV infection and was more prominent in patients that had high levels of soluble CD163 (sCD163), a newly identified plasmatic HIV progression biomarker. Among the enzymes, histone acetyltransferase 1 (HAT1) was the best epigenetic biomarker correlated with HIV sCD163 high patients. In conclusion, we confirmed that HIV impairs effector functions of monocytes and these alterations are associated with epigenetic changes that once identified could be used as targets in therapies aiming the reduction of the systemic activation state found in HIV patients. (AU)

FAPESP's process: 11/12512-0 - Evaluation of epigenetic and immune alterations of macrophages from patients infected with human immunodeficiency virus in response to Mycobacterium tuberculosis
Grantee:Milena Sobral Espíndola
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 11/12199-0 - Elucidation of innate immune response dysfunction of HIV patients: the underlying mechanisms amongst immunological and epigenetic modifications
Grantee:Fabiani Gai Frantz
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 17/05365-8 - Functional biomarkers of the immune response in human tuberculosis
Grantee:Fabiani Gai Frantz
Support Opportunities: Regular Research Grants