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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

MOG-IgG-Associated Optic Neuritis, Encephalitis, and Myelitis: Lessons Learned From Neuromyelitis Optica Spectrum Disorder

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dos Passos, Giordani Rodrigues [1] ; Oliveira, Luana Michelli [2] ; da Costa, Bruna Klein [1] ; Apostolos-Pereira, Samira Luisa [2] ; Callegaro, Dagoberto [2] ; Fujihara, Kazuo [3] ; Sato, Douglas Kazutoshi [2, 1]
Total Authors: 7
[1] Pontifical Catholic Univ Rio Grande Sul PUCRS, Sch Med, Brain Inst Rio Grande BraIns, Porto Alegre, RS - Brazil
[2] Univ Sao Paulo FMUSP, Fac Med, Hosp Clin, Dept Neurol, Sao Paulo - Brazil
[3] Fukushima Med Univ, Southern TOHOKU Res Inst Neurosci, Multiple Sclerosis & Neuromyelitis Opt Ctr, Dept Multiple Sclerosis Therapeut, Koriyama, Fukushima - Japan
Total Affiliations: 3
Document type: Review article
Source: FRONTIERS IN NEUROLOGY; v. 9, APR 4 2018.
Web of Science Citations: 28

Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been found in some cases diagnosed as seronegative neuromyelitis optica spectrum disorder (NMOSD). MOG-IgG allowed the identification of a subgroup with a clinical course distinct from that of NMOSD patients who are seropositive for aquaporin-4-IgG antibodies. MOG-IgG is associated with a wider clinical phenotype, not limited to NMOSD, with the majority of cases presenting with optic neuritis (ON), encephalitis with brain demyelinating lesions, and/or myelitis. Therefore, we propose the term MOG-IgG-associated Optic Neuritis, Encephalitis, and Myelitis (MONEM). Depending on the clinical characteristics, these patients may currently be diagnosed with NMOSD, acute disseminated encephalomyelitis, pediatric multiple sclerosis, transverse myelitis, or ON. With specific cell-based assays, MOG-IgG is emerging as a potential biomarker of inflammatory disorders of the central nervous system. We review the growing body of evidence on MONEM, focusing on its clinical aspects. (AU)

FAPESP's process: 15/23968-6 - Linically suspected neuromyelitis optica associated to anti-MOG antibodies
Grantee:Luana Michelli Oliveira de Paula Salles
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)