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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of blood thiamine concentrations on mortality: Influence of nutritional status

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Leite, Heitor Pons [1] ; Peixoto de Lima, Lucio Flavio [2] ; Taddei, Jose Augusto de A. C. [1] ; Paes, Angela Tavares [3]
Total Authors: 4
[1] Univ Fed Sao Paulo, Dept Pediat, Discipline Nutr & Metab, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Pediat, Pediat Intens Care Unit, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Appl Stat, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: NUTRITION; v. 48, p. 105-110, APR 2018.
Web of Science Citations: 2

Objective: To test the hypothesis that low blood thiamine concentrations in malnourished critically ill children are associated with higher risk of 30-d mortality. Methods: Prospective cohort study in 202 consecutively admitted children who had whole blood thiamine concentrations assessed on admission and on days 5 and 10 of intensive care unit (ICU) stay. The primary outcome variable was 30-d mortality. Mean blood thiamine concentrations within the first 10 d of ICU stay, age, sex, malnutrition, C-reactive protein concentration, Pediatric Index of Mortality 2 score, and severe sepsis/septic shock were the main potential exposure variables for outcome. Results: Thiamine deficiency was detected in 61 patients within the first 10 d of ICU stay, 57 cases being diagnosed on admission and 4 new cases on the 5th d. C-reactive protein concentration during ICU stay was independently associated with decreased blood thiamine concentrations (P = 0.003). There was a significant statistical interaction between mean blood thiamine concentrations and malnutrition on the risk of 30-d mortality (P = 0.002). In an adjusted analysis, mean blood thiamine concentrations were associated with a decrease in the mortality risk in malnourished patients (odds ratio = 0.85; 95% confidence interval {[}CI]: 0.73-0.98; P = 0.029), whereas no effect was noted for well-nourished patients (odds ratio: 1.03; 95% Cl: 0.94-1.13; P = 0.46). Conclusions: Blood thiamine concentration probably has a protective effect on the risk of 30-d mortality in malnourished patients but not in those who were well nourished. (C) 2017 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 05/01559-5 - Thiamin and riboflavin in blood and severity of illness in children admitted in a pediatric intensive care unit
Grantee:Heitor Pons Leite
Support Opportunities: Regular Research Grants