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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of Proanthocyanidin-enriched extracts on the inhibition of wear and degradation of dentin demineralized organic matrix

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Boteon, Ana Paula [1] ; Kato, Melissa Thiemi [2] ; Rabelo Buzalaf, Marilia Afonso [3] ; Prakki, Anuradha [4] ; Wang, Linda [1] ; Rios, Daniela [5] ; Honorio, Heitor Marques [5]
Total Authors: 7
[1] Univ Sao Paulo, Bauru Sch Dent, Dept Restorat Dent Endodont & Dent Mat, Bauru, SP - Brazil
[2] Fac Ctr Oeste Paulista FACOP, Dept Post Graduat, Piratirzinga, SP - Brazil
[3] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Bauru - Brazil
[4] Univ Toronto, Fac Dent, Dept Clin Sci Restorat, Toronto, ON - Canada
[5] Univ Sao Paulo, Bauru Sch Dent, Dept Pediat Dent Orthodont & Publ Hlth, Bauru, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: ARCHIVES OF ORAL BIOLOGY; v. 84, p. 118-124, DEC 2017.
Web of Science Citations: 0

Objectives: The aim of this study was to evaluate the effect of Cranberry and Grape seed-enriched extract gels in inhibiting wear and degradation of demineralized organic matrix (DOM). Design: 225 dentin specimens obtained from bovine incisors were randomly allocated into 5 groups (n = 45): 10% Grape seed extract gel (GSE), 10% Cranberry extract gel (CE), 0.012% Chlorhexidine gel (CX), 1.23% NaF gel (F), and no active compound gel (P, placebo). Before the treatments, samples were demineralized by immersion in 0.87 M citric acid, pH 2.3 (36 h). Then, the studied gels were applied once over dentin for 1 min. Next, the samples were immersed in artificial saliva containing collagenase obtained from Clostridium histolyticum for 5 days. The response variable for dentin wear was depth of dentin loss measured by profilometry and for collagen degradation was hydroxyproline determination. Data were analyzed by ANOVA followed by Tukey's test and Pearson Correlation Test (p < 0.05). Results: Grape seed extract significantly reduced dentin wear compared to the other groups (p < 0.05). Cranberry extract and Chlorhexidine did not differ statistically and were able to reduce wear when compared to NaF and placebo treatments. The hydroxyproline analysis showed that there was no significant difference among groups for all treatments (p < 0.05). Correlation analysis showed a significant correlation between the amount of degraded DOM evaluated by profilometry and the determination of hydroxyproline. Conclusion: Cranberry extract was able to reduce the dentin wear and collagen degradation, likely due to the proanthocyanidin content and its action. Therefore, Cranberry could be suggested as an interesting natural-based agent to prevent dentin erosion. (AU)

FAPESP's process: 14/26754-4 - Inhibitory effect of organic matrix degradation and wear of Cranberry and proanthocyanidin gels on dentin submitted to dental erosion
Grantee:Heitor Marques Honório
Support Opportunities: Regular Research Grants
FAPESP's process: 14/25833-8 - Effect of cranberry and proanthocyanidin in inhibiting wear and degradation of the organic matrix of demineralised dentine
Grantee:Ana Paula Boteon
Support Opportunities: Scholarships in Brazil - Master