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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Epigenetic Regulatory Mechanisms Induced by Resveratrol

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Author(s):
Santos Fernandes, Guilherme Felipe [1, 2] ; Bernardes Silva, Gabriel Dalio [1] ; Pavan, Aline Renata [1] ; Chiba, Diego Eidy [1] ; Chin, Chung Man [1] ; Dos Santos, Jean Leandro [1]
Total Authors: 6
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara - Brazil
[2] Sao Paulo State Univ UNESP, Inst Chem, BR-14800060 Araraquara - Brazil
Total Affiliations: 2
Document type: Review article
Source: NUTRIENTS; v. 9, n. 11 NOV 2017.
Web of Science Citations: 19
Abstract

Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases and metabolic disorders. Nevertheless, the mechanism of action of RVT in all of these conditions is not completely understood, as it can modify not only biochemical pathways but also epigenetic mechanisms. In this paper, we analyze the biological activities exhibited by RVT with a focus on the epigenetic mechanisms, especially those related to DNA methyltransferase (DNMT), histone deacetylase (HDAC) and lysine-specific demethylase-1 (LSD1). (AU)

FAPESP's process: 15/19531-1 - Targeting histone deacetylase (HDAC-1 and HDAC-2) as mechanisms to induce fetal hemoglobin in sickle cell disease
Grantee:Jean Leandro dos Santos
Support Opportunities: Regular Research Grants
FAPESP's process: 16/08470-4 - DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW DERIVATIVES OF LAPDESF FTD-AO AND LAPDESF FTD-TAU SERIES WITH POTENTIAL ACTIVITY IN THE TREATMENT OF ALZHEIMER'S DISEASE
Grantee:Diego Eidy Chiba
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 16/08880-8 - Synthesis and pharmacological evaluation of Bromodomain inhibitors (BRD-3) designed as fetal hemoglobin inducers
Grantee:Gabriel Dalio Bernardes da Silva
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 16/09502-7 - Design, synthesis and antitubercular activity of new oxazolidinones useful for the treatment of multidrug-resistant tuberculosis
Grantee:Guilherme Felipe dos Santos Fernandes
Support Opportunities: Scholarships in Brazil - Doctorate