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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Urinary beta-trace protein gene expression analysis in type 2 diabetes mellitus patients

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Author(s):
Bacci, Marcelo Rodrigues [1] ; Aguiar Alves, Beatriz da Costa [1] ; Cavallari, Marina Romera [1] ; Azzalis, Ligia Ajaime [2] ; de Rozier-Alves, Ross Martin [1] ; Perez, Matheus Moreira [1] ; Chehter, Ethel Zimberg [1] ; Pereira, Edimar Cristiano [2] ; Affonso Fonseca, Fernando Luiz [1, 2]
Total Authors: 9
Affiliation:
[1] ABC, Fac Med, Santo Andre, SP - Brazil
[2] Univ Fed Sao Paulo, Diadema, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Einstein (São Paulo); v. 15, n. 4, p. 441-444, OCT-DEC 2017.
Web of Science Citations: 1
Abstract

Objective: To evaluate the gene expression of beta-trace protein in urine of diabetic patients, with no reduction in glomerular filtration rate, which was defined as below 60mL/min/1.73m(2). Methods: Type 2 diabetes mellitus patients were recruited, and a group of non-diabetic individuals served as control. Beta-trace protein gene expression was analyzed by quantitative PCR. Blood samples were collected to establish glucose levels and baseline kidney function. Accuracy was analyzed using ROC curves. Results: Ninety type 2 diabetes mellitus patients and 20 non-diabetic individuals were recruited. The area under the curve was 0.601, sensitivity of 20% and specificity of 89.47%. Among diabetic participants, 18% showed an expression above the cutoff point. Conclusion: These results of accuracy of beta-trace protein gene expression in urine of diabetic patients are promising, although they did not achieve a higher area under the curve level. (AU)

FAPESP's process: 14/04596-8 - Early acute kidney injury biomarkers study in type 2 diabetes
Grantee:Fernando Luiz Affonso Fonseca
Support type: Regular Research Grants