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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A Perspective Discussion on Rising Pesticide Levels and Colon Cancer Burden in Brazil

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Uyemura, Sergio Akira [1] ; Stopper, Helga [2] ; Martin, Francis L. [3] ; Kannen, Vinicius [1]
Total Authors: 4
[1] Univ Sao Paulo, Dept Toxicol Bromatol & Clin Anal, Ribeirao Preto - Brazil
[2] Univ Wurzburg, Dept Toxicol, Wurzburg - Germany
[3] Univ Cent Lancashire, Sch Pharm & Biomed Sci, Preston, Lancs - England
Total Affiliations: 3
Document type: Journal article
Source: FRONTIERS IN PUBLIC HEALTH; v. 5, OCT 16 2017.
Web of Science Citations: 3

Agriculture is a mainstay of many developing countries' economy, such as Brazil. According to the Food and Agriculture Organization of the United Nations, Brazil is the major global consumer of pesticides. Irrespective of the fact that the International Agency for Research on Cancer suggests that pesticides promote human cancer risk, a prospective study reports that colorectal cancer (CRC) burden will increase in developing countries by approximately 60% in the coming decades. Here, we review the literature and public data from the Brazilian Federal Government to explore why pesticides levels and new cases of colon cancer (CC) are rising rapidly in the country. CC incidence is the second most common malignancy in men and women in the South and the Southeast of Brazil. However, while these regions have almost doubled their pesticide levels and CC mortality in 14 years, the amount of sold pesticides increased 5.2-fold with a corresponding 6.2-fold increase in CC mortality in Northern and Northeastern states. Interestingly, mortality from endocrine, nutritional, and metabolic diseases are rapidly increasing, in close resemblance with the pesticide detection levels in food. Taken together, we discuss the possibility that pesticides might alter the risk of CC. (AU)

FAPESP's process: 14/06428-5 - Differentiating the effects of epithelial from the neural serotoninergic signalling during inflammation-related colon cancer
Grantee:Vinicius Kannen Cardoso
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 15/01723-1 - Differentiating the effects of epithelial from the neural serotonergic signalling during the development of colon carcinogenesis
Grantee:Vinicius Kannen Cardoso
Support Opportunities: Scholarships in Brazil - Young Researchers