Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Anatomical specificity of the brain in the modulation of Neuroglobin and Cytoglobin genes after chronic bisphenol a exposure

Full text
da Conceicao, Rodrigo Rodrigues [1] ; de Souza, Janaina Sena [1] ; de Oliveira, Kelen Carneiro [1] ; de Barros Maciel, Rui Monteiro [1] ; Romano, Marco Aurelio [2] ; Romano, Renata Marino [2] ; Dias da Silva, Magnus Regios [1] ; Chiamolera, Maria Izabel [1] ; Giannocco, Gisele [3, 1, 4]
Total Authors: 9
[1] Univ Fed Sao Paulo Unifesp, EPM, Lab Mol & Translat Endocrinol, Dept Med, Sao Paulo, SP - Brazil
[2] State Univ Ctr Oeste, Dept Pharm, Curitiba, Parana - Brazil
[3] Univ Fed Sao Paulo, Dept Biol Sci, Diadema, SP - Brazil
[4] Univ Fed So Paulo UNIFESP, Dept Med, Lab Endocriol Mol & Translac, Rua Pedro Toledo, Vila Clementino, BR-04039032 Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: METABOLIC BRAIN DISEASE; v. 32, n. 6, p. 1843-1851, DEC 2017.
Web of Science Citations: 2

The aim of this study was to investigate the influence of Bisphenol A (BPA) exposure on Neuroglobin (Ngb) and Cytoglobin (Cygb) as well as oxidative stress gene expression in the cerebellum, hippocampus, hypothalamus and cortex. Male Wistar rats were randomly divided into 3 groups: Control and two groups receiving 2 different daily BPA dosages, 5 or 25 mg/kg from postnatal day 50 (PND50) through PND90 and they were euthanized at PND105. In the cortex, we found an increase in Ngb gene expression and also in superoxide dismutase 1 and Catalase (Cat). In the cerebellum, we found an increase in Ngb and Cat, in the hypothalamus, there was a decrease in Cygb and an increase in glutathione peroxidase and Cat and in hypoxia-inducible factor 1 alpha (Hif1 alpha) at the low dosage and a decrease in Hif1 alpha at the high BPA dosage. Finally, in the hippocampus, we observed a decrease in Ngb and Cygb and an increase in Hif1 alpha. In summary, BPA promotes the modulation of both Ngb and Cygb, but such changes occur by different mechanisms depending on the exposure dose and anatomical area. (AU)

FAPESP's process: 13/26851-7 - In vivo study of the effects of the endocrine disruptors glyphosate and bisphenol-A on the hypothalamic-pituitary-thyroid axis
Grantee:Maria Izabel Chiamolera
Support Opportunities: Regular Research Grants