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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Thyrotrophin levels and coronary artery calcification: Cross-sectional results of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

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Peixoto de Miranda, Erique Jose F. [1] ; Bittencourt, Marcio Sommer [1] ; Staniak, Henrique Lane [1] ; Pereira, Alexandre C. [2] ; Foppa, Murilo [3] ; Santos, Itamar S. [1] ; Lotufo, Paulo A. [1] ; Bensenor, Isabela M. [1]
Total Authors: 8
[1] Univ Sao Paulo, Univ Hosp, Ctr Pesquisa Clin, Sao Paulo - Brazil
[2] Inst Coracao, Lab Genet, Sao Paulo - Brazil
[3] Univ Fed Rio Grande do Sul, Fac Med, Porto Alegre, RS - Brazil
Total Affiliations: 3
Document type: Journal article
Source: CLINICAL ENDOCRINOLOGY; v. 87, n. 5, p. 597-604, NOV 2017.
Web of Science Citations: 3

Objective: There is little information about the association between thyrotrophin (TSH) levels and coronary artery calcification (CAC). Our aim was to analyse the association between TSH quintiles and subclinical atherosclerosis measured by CAC, using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) Design: Cross-sectional study. Patients: We excluded individuals using medications that affect thyroid function and who self-reported cardiovascular disease. We included euthyroid subjects and individuals with subclinical hypothyroidism (SCHypo) and subclinical hyperthyroidism (SCHyper). Logistic regression models evaluated CAC >100 Agatston units as the dependent variable, and increasing quintiles of TSH as the independent variable, adjusted for demographic and cardiovascular risk factors. Results: Our sample included 3836 subjects, mean age 49years (interquartile range 44-56); 1999 (52.1%) were female, 3551 (92.6%) were euthyroid, 239 (6.2%) had SCHypo and 46 (1.2%) had SCHyper. The frequency of women, White people and never smokers as well as body mass index and insulin resistance increased according to quintiles. The 1st quintile for TSH (0-0.99mIU/L) was associated with CAC >100, using the 3rd quintile (1.39-1.85mIU/L) as reference (adjusted OR=1.57, 95% CI: 1.05-2.35, P=.027), but no association was shown for the 5th quintile (2.68-35.5mIU/L) compared to the 3rd. Restricting the analysis to euthyroid subjects did not change the results. For women, but not for men, we observed a U-shaped curve with 1st and 5th TSH quintiles associated with CAC>100. Conclusion: Low and low-normal (1st quintile) TSH levels were associated with CAC>100Agatston units in a sample with subclinical thyroid disorders and euthyroid subjects. (AU)

FAPESP's process: 11/12256-4 - Calcium score and coronary atherosclerosis in an adult cohort
Grantee:Paulo Andrade Lotufo
Support Opportunities: Regular Research Grants