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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)


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Fassini, Aline [1] ; Scopinho, America A. [1] ; Alves, Fernando H. F. [1] ; Fortaleza, Eduardo A. T. [1] ; Correa, Fernando M. A. [1]
Total Authors: 5
[1] Univ Sao Paulo, Dept Pharmacol, Sch Med Ribeirao Preto, Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Neuroscience; v. 364, p. 164-174, NOV 19 2017.
Web of Science Citations: 1

The medial preoptic area (mPOA) participates in the temperature and cardiovascular control. The mPOA receives inputs from limbic structures and sends projections to hypothalamus and brainstem. Moreover, stress elicits pronounced neuronal activation in mPOA, suggesting its involvement in central neural pathway mediating stress responses. In the present study, we report the effect of acute mPOA neurotransmission inhibition using cobalt chloride (CoCl2-nonselective synapse blocker) on the mean arterial pressure (MAP), heart rate (HR), body and tail temperature (T-body and T-tail, respectively), as well as on the HR component of baroreflex. We also verified the participation of mPOA in the autonomic changes evoked by acute restraint stress (RS). Our results demonstrated that microinjection of CoCl2 into mPOA caused tachycardia, hyperthermia and a Ttail decrease, without altering MAP. The inhibition of mPOA with CoCl2 increased the sympathetic component of cardiac baroreflex when assessed 10 min after its administration. In addition, pretreatment of mPOA with CoCl2 increased RS-evoked tachycardic and hyperthermic responses evoked by RS when compared with aCSFtreated animals, without affecting the RS-evoked pressor response and the fall in Ttail. In summary, our results suggest that mPOA exerts a tonic inhibitory influence on the sympathetic cardiac tone under both rest and stress conditions, modulating negatively the sympathetic component of baroreflex. Results also confirm the mPOA involvement in the control of body temperature because its inhibition was followed by a sustained increase in body temperature and vasoconstriction in the tail artery territory. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 13/13721-8 - Study of the involvement of endocannabinoid system into the prefrontal medial córtex on food intake of rats.
Grantee:América Scopinho Augusto
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/00249-9 - Involvement of opioid neurotransmission of the medial amygadala in the mediation of autonomic and hormonal responses evoked by restraint stress in rats
Grantee:Aline Fassini
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 12/18556-2 - Involvement of the glutamatergic system in the paraventricular and supra-optic nucleus on the modulation of the cardiovascular system and the vasopressin and oxytocin release, in rats submitted to osmotic stimuli.
Grantee:Eduardo Albino Trindade Fortaleza
Support type: Scholarships in Brazil - Post-Doctorate