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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Clinical and microbiological profile of chronic Burkholderia cepacia complex infections in a cystic fibrosis reference hospital in Brazil

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da Costa Capizzani, C. P. [1] ; Cacador, N. C. [1] ; Torres, L. A. G. M. M. [2] ; Tonani, L. [1] ; Vandamme, P. [3] ; da Costa Darini, A. L. [4, 1]
Total Authors: 6
[1] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Clin Anal Toxicol & Bromatol, Ribeirao Preto - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pediat, Cyst Fibrosis Referral Serv, Clin Hosp, Ribeirao Preto - Brazil
[3] Univ Ghent, Microbiol Lab, Ghent - Belgium
[4] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Ribeirao Preto - Brazil
Total Affiliations: 4
Document type: Journal article
Web of Science Citations: 2

Burkholderia sp. infections are extremely complex in cystic fibrosis (CF) patients, especially considering the lack of knowledge regarding its behavior, its relationship with prognosis, as well as its transmissibility and multidrug resistance features. This study evaluated the frequency of chronic infection by Burkholderia, using microbiological and clinical data. Ninety-eight patients with CF attended from July 2011 to April 2014 in a Brazilian reference hospital were included. Antimicrobial activity, molecular epidemiology, Shwachman score, body mass index, exacerbations, and lung function were analyzed. Nine patients had chronic colonization, and all of them showed preserved pulmonary function levels, body mass index, and Shwachman score. Meropenem was the most effective antibiotic; however, divergent results were shown by other studies. Cross-contamination may have occurred in only two unrelated patients of different ages, who were colonized by B. vietnamiensis, which does not occur frequently. Twelve new sequence types (STs) were identified and three STs have presented intercontinental distribution. None of the patients presented known epidemic strains. In conclusion, a relatively low number of patients with chronic colonization and suspected cross-infection were identified. Different from other studies that have found CF patients chronically colonized with Burkholderia sp. having a greater deterioration of lung function, more frequent antibiotic therapy, and increased mortality, in the current study, the patients showed good clinical outcomes and favorable options for antibiotics therapy. This study also updated the epidemiological database, which facilitates the multicentric collaborative analysis and assists in the control of global infection by these pathogens. (AU)

FAPESP's process: 13/13455-6 - Epidemiology of bacterial infections in patients with cystic fibrosis involving Achromobacter and Burkholderia cepacia complex bacteria
Grantee:Carolina Paulino da Costa Capizzani
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 13/13358-0 - Classical and molecular epidemiology of Pseudomonas aeruginosa isolated from patients with Cystic Fibrosis
Grantee:Natália Candido Caçador
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 14/14494-8 - Molecular epidemiology of gram-negative bacteria and genetic of antibiotic resistance
Grantee:Ana Lúcia da Costa Darini
Support Opportunities: Research Projects - Thematic Grants